Dietary intake and risk of lung cancer in women who never smoked.
Dietary intake and risk of lung cancer in women who never smoked.
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DOI：
10.1080/01635589209514195
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
E. Candelora;H. Stockwell;Adam W. Armstrong;P. A. Pinkham
中科院分区：
文献类型：
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作者：
E. Candelora;H. Stockwell;Adam W. Armstrong;P. A. Pinkham
进行了一项病例对照研究，以检查饮食因素对从不吸烟的妇女患肺癌风险的影响。这项研究包括124例经组织学证实的肺癌和263例社区对照。饮食数据的收集利用国家癌症研究所（块）的食物频率问卷的简化版本。这项分析的结果，调整了年龄，教育和总热量，表明与总蔬菜消费量和胡萝卜素摄入量相关的强有力的保护作用。蔬菜消费量最高四分位数的个体经历了最大的风险降低，比值比（OR）为0.2，[置信区间（CI）0.1-0.5]。所有蔬菜组合的效果大于单独的绿色和黄色蔬菜（最高四分位数OR 0.4，CI 0.2-0.7）。类似地，总胡萝卜素的保护作用（最高四分位数OR 0.3，CI 0.1-0.6）略大于单独β-胡萝卜素的保护作用（最高四分位数OR 0.4，CI 0.2-0.8）。在我们的人群中，视黄醇摄入与肺癌风险降低无关。肺癌风险与维生素C摄入量之间存在负相关，尽管注意到统计学上的显著趋势，但并不显著。
A case-control study was conducted to examine the influence of dietary factors on the risk of developing lung cancer among women who have never smoked cigarettes. This study included 124 cases of histologically confirmed carcinoma of the lung and 263 community-based controls. Dietary data were collected utilizing the reduced version of the National Cancer Institute (Block) food frequency questionnaire. The results of this analysis, adjusted for age, education, and total calories, indicated a strong protective effect associated with total vegetable consumption and intake of carotene. Individuals in the highest quartile of vegetable consumption experienced the greatest decreased risk with an odds ratio (OR) of 0.2, [confidence interval (CI) 0.1-0.5]. The effect of all vegetables combined was greater than that of green and yellow vegetables alone (highest quartile OR 0.4, CI 0.2-0.7). Similarly, the protective effect of total carotene (highest quartile OR 0.3, CI 0.1-0.6) was somewhat greater than that of beta-carotene alone (highest quartile OR 0.4, CI 0.2-0.8). Retinol intake was not associated with a decreased risk of lung cancer in our population. There was an inverse association between lung cancer risk and vitamin C intake, which was not significant, although a statistically significant trend was noted.