CSF proteomic fingerprints for HIV-associated cognitive impairment
CSF proteomic fingerprints for HIV-associated cognitive impairment
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DOI：
10.1016/j.jneuroim.2007.08.004
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发表时间：
2007-12-01
影响因子：
3.3
通讯作者：
Melendez, Loyda M.
中科院分区：
文献类型：
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作者：
Laspiur, Juliana Perez;Anderson, Eric R.;Melendez, Loyda M.
尽管广泛使用抗逆转录病毒疗法，但认知障碍仍然是晚期人类免疫缺陷病毒（艾滋病毒）感染的主要并发症。通过排除具有巨大潜在用途的生物标志物来进行诊断。因此，我们使用了一个综合的蛋白质组学平台，以评估脑脊液蛋白质谱从50 HIV-1血清阳性的西班牙裔妇女。在38种蛋白质中，有9种在认知障碍（Cl）患者中是独特的。这些蛋白质与细胞信号传导、结构功能和抗氧化活性有关。这项工作突出了，在一个初步的方式，利用蛋白质组学分析的生物标志物发现HIV-1相关的认知功能障碍。由爱思唯尔公司出版
Cognitive impairment remains a major complication of advanced human immunodeficiency virus (HIV) infection despite the widespread use of anti-retroviral therapy. Diagnosis is made by exclusion making biomarkers of great potential use. Thus, we used an integrated proteomics platform to assess cerebrospinal fluid protein profiles from 50 HIV-1 seropositive Hispanic women. Nine of 38 proteins identified were unique in those patients with cognitive impairment (Cl). These proteins were linked to cell signaling, structural function, and antioxidant activities. This work highlights, in a preliminary manner, the utility of proteomic profiling for biomarker discovery for HIV-1 associated cognitive dysfunction. Published by Elsevier B.V.