ACTIONS OF ION-TRANSPORT PEPTIDE FROM LOCUST CORPUS CARDIACUM ON SEVERAL HINDGUT TRANSPORT PROCESSES
ACTIONS OF ION-TRANSPORT PEPTIDE FROM LOCUST CORPUS CARDIACUM ON SEVERAL HINDGUT TRANSPORT PROCESSES
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发表时间：
1992-12
期刊：
影响因子：
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通讯作者：
N. Audsley;C. Mcintosh;J. Phillips
中科院分区：
文献类型：
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作者：
N. Audsley;C. Mcintosh;J. Phillips
1. Schistocerca gregaria 离子转运肽 (Scg-ITP) 是一种从蝗虫贲门体中分离出来的神经肽，它以剂量依赖性方式刺激回肠 Cl- 转运 (Isc)，并导致 Na+、K+ (IK) 和液体重吸收 (Jv) 增加，正如之前在贲门体粗提物和环 AMP 中观察到的那样。与环 AMP 不同，Scg-ITP 不会刺激回肠 NH4+ 分泌。 2.回肠中的H+分泌(JH)不受环AMP影响，几乎被Scg-ITP完全消除。尽管 ITP 可能通过环 AMP 作为第二信使刺激 NaCl、KCl 和液体重吸收，但它显然通过不同的细胞内途径影响 JH。 3. Scg-ITP 不太可能是先前报道的作用于直肠的氯离子转运刺激激素，因为它不会产生最大的直肠 Isc 反应，并且对直肠 Jv（Cl-依赖性）或 IK 没有影响。
1. Schistocerca gregaria ion-transport peptide (Scg-ITP), a neuropeptide isolated from locust corpora cardiaca, stimulates ileal Cl- transport (Isc) in a dose-dependent manner and causes increases in Na+, K+ (IK) and fluid reabsorption (Jv) as previously observed with crude extracts of corpus cardiacum and with cyclic AMP. Unlike cyclic AMP, Scg-ITP does not stimulate ileal NH4+ secretion. 2. H+ secretion (JH) in the ileum, which is not affected by cyclic AMP, is almost completely abolished by Scg-ITP. Although ITP may act via cyclic AMP as second messenger to stimulate NaCl, KCl and fluid reabsorption, it apparently acts through a different intracellular pathway to influence JH. 3. Scg-ITP is unlikely to be the chloride transport stimulating hormone previously reported to act on the rectum, because it did not produce a maximum rectal Isc response and had no effect on either rectal Jv (which is Cl--dependent) or IK.