Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation
Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation
复制标题
在有丝分裂刺激过程中，凝血酶和表皮生长因子与细胞表面受体相连
作者：
J. Baker;R. Simmer;K. Glenn;Dennis Cunningham
THERE is much evidence that interaction with specific cell surface receptors is a key event in the action of polypeptide hormones and growth factors. Many analyses of hormone–receptor interactions have been carried out based on the assumption that hormone binding to the cell receptors is a reversible reaction1–3. Indeed, many studies have demonstrated that bound hormones dissociate from their receptors. However, in most systems the possibility could not be excluded that a significant fraction of the hormone molecules that bind to cells become linked to their receptors. Our present studies with the polypeptide mitogens 125I-thrombin and 125I-epidermal growth factor (125I-EGF) show that a significant percentage of the molecules that are specifically bound on human fibroblasts become linked to cell surface receptors. This finding has broad implications for the way in which these molecules might stimulate cell division. It also raises the question of whether linkage of polypeptide hormones to their receptors is a general phenomenon.
