Human β-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response
Human β-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response
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DOI：
10.1038/icb.2008.56
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发表时间：
2008-11-01
影响因子：
4
通讯作者：
Brogden, Kim A.
中科院分区：
文献类型：
--
作者：
Pingel, Lindsey C.;Kohlgraf, Karl G.;Brogden, Kim A.
粘膜分泌物和组织中的调节机制识别抗原并减弱促炎细胞因子应答。在此，我们询问人β-防御素3（HBD 3）是否作为细胞因子信号传导的上游抑制因子，其结合并减弱促炎细胞因子对重组血凝素B（rHag B）的反应，重组血凝素B是来自牙龈卟啉单胞菌菌株381的非菌毛粘附素。我们发现，HBD 3结合到固定化的rHagB和产生一个显着更高的共振单元信号在表面等离子体共振光谱分析，比HBD 2和HBD 1，用作控制防御素。此外，我们发现HBD 3显著减弱（P
Regulatory mechanisms in mucosal secretions and tissues recognize antigens and attenuate pro-inflammatory cytokine responses. Here, we asked whether human beta-defensin 3 (HBD3) serves as an upstream suppressor of cytokine signaling that binds and attenuates pro-inflammatory cytokine responses to recombinant hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis strain 381. We found that HBD3 binds to immobilized rHagB and produces a significantly higher resonance unit signal in surface plasmon resonance spectroscopic analysis, than HBD2 and HBD1 that are used as control defensins. Furthermore, we found that HBD3 significantly attenuates (P