BDNF is required for the normal development of taste neurons in vivo
BDNF is required for the normal development of taste neurons in vivo
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BDNF 是体内味觉神经元正常发育所必需的
DOI：
10.1097/00001756-199703030-00039
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发表时间：
1997
期刊：
影响因子：
1.7
通讯作者：
B. Oakley
中科院分区：
文献类型：
--
作者：
Chunxiao Zhang;A. Brandemihl;David Lau;A. Lawton;B. Oakley
新生trkB无效突变小鼠（−/−）的腭状味觉上皮缺乏神经支配。这促使对对应于酪氨酸激酶受体B（Trk B）的三种神经营养因子配体的无效突变小鼠进行评价：脑源性神经营养因子（BDNF）、神经营养因子（NT）3、NT 4。nt 3 −/−小鼠和nt 4 −/−小鼠的齿状味觉上皮表现正常。只有bdnf−/−小鼠的乳头状突起发育不良，神经支配稀疏，并且缺乏高达98%的味蕾。这三个缺陷都存在。例如，12天大的bdnf−/−小鼠的乳头状突起的神经支配明显不如7天大或新生bdnf+/+小鼠的乳头状突起。新生bdnf−/−小鼠的叶状味觉乳头也有类似的缺陷。我们的结论是味觉神经元的正常发育需要BDNF。
THE vallate gustatory epithelium of neonatal trkB null mutant mice (−/−) lacked innervation. This prompted the evaluation of null mutant mice corresponding to the three neurotrophin ligands for tyrosine kinase receptor B (TrkB): brain-derived neurotrophic factor (BDNF), neurotrophin (NT)3, NT4. The vallate gustatory epithelium of nt3−/− mice and of nt4−/− mice appeared normal. Only bdnf−/− mice had a vallate papilla that was stunted, sparsely innervated, and lacked up to 98% of its taste buds. All three defects persisted. For example, the vallate papilla of 12-day-old bdnf−/− mice remained markedly less well innervated than the vallate of 7-day-old or newborn bdnf+/+ mice. The foliate taste papillae of neonatal bdnf−/− mice had similar defects. We conclude that the normal development of taste neurons requires BDNF.