Posttraumatic Stress Disorder and Completed Suicide
Posttraumatic Stress Disorder and Completed Suicide
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DOI：
10.1093/aje/kwp456
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发表时间：
2010-03-15
影响因子：
5
通讯作者：
Lash, Timothy L.
中科院分区：
文献类型：
--
作者：
Gradus, Jaimie L.;Qin, Ping;Lash, Timothy L.
大多数关于创伤后应激障碍（PTSD）和自杀的研究都集中在自杀意念或企图上；在以人群为基础的样本中，没有关于创伤后应激障碍和自杀之间关系的已知研究报告。本研究在以人群为基础的样本中调查了创伤后应激障碍和自杀之间的关系。数据来自丹麦全国卫生和行政登记处，其中包括丹麦所有540万居民的数据。包括1994年1月1日至2006年12月31日之间的所有自杀事件，并从所有丹麦居民的样本中选择对照。使用这种嵌套病例对照设计，作者检查了9612例自杀病例和199306例对照，这些对照在性别、出生日期和时间上与病例相匹配。38例自杀患者（0.40%）和95例对照组（0.05%）被诊断为PTSD。PTSD与自杀的比值比为9.8（95%可信区间：6.7,15）。在控制了精神病学和人口学混杂因素后，PTSD与自杀自杀之间的关联仍然存在（优势比= 5.3,95%可信区间：3.4,8.1）。此外，创伤后应激障碍和抑郁症患者的自杀率高于基于其独立影响的预期。总之，基于国际疾病和相关健康问题统计分类第十版的创伤后应激障碍登记诊断是自杀的一个危险因素。
Most research regarding posttraumatic stress disorder (PTSD) and suicide has focused on suicidal ideation or attempts; no known study of the association between PTSD and completed suicide in a population-based sample has been reported. This study examined the association between PTSD and completed suicide in a population-based sample. Data were obtained from the nationwide Danish health and administrative registries, which include data on all 5.4 million residents of Denmark. All suicides between January 1, 1994, and December 31, 2006, were included, and controls were selected from a sample of all Danish residents. Using this nested case-control design, the authors examined 9,612 suicide cases and 199,306 controls matched to cases on gender, date of birth, and time. Thirty-eight suicide cases (0.40%) and 95 controls (0.05%) were diagnosed with PTSD. The odds ratio associating PTSD with suicide was 9.8 (95% confidence interval: 6.7, 15). The association between PTSD and completed suicide remained after controlling for psychiatric and demographic confounders (odds ratio = 5.3, 95% confidence interval: 3.4, 8.1). Additionally, persons with PTSD and depression had a greater rate of suicide than expected based on their independent effects. In conclusion, a registry-based diagnosis of PTSD based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, is a risk factor for completed suicide.