Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
复制标题
DOI：
10.1136/ard.61.7.617
复制
发表时间：
2002-07-01
影响因子：
27.4
通讯作者：
Shimada, S
中科院分区：
文献类型：
--
作者：
Miyazaki, T;Wada, M;Shimada, S
目的：验证基线动态负荷可预测内侧间隔性膝骨性关节炎(OA)患者放射学疾病进展的假设。方法：收集1991-93年间收治的106例膝关节内侧间隔性骨关节炎患者，通过疼痛评估、X线片和步态分析收集基线数据。在六年的随访中，74名患者再次接受检查以评估放射学变化。结果：在32例有疾病进展的患者中，疼痛程度较无疾病进展者(n=42)更重，内收矩高于无进展者(n=42)。在六年的时间里，关节间隙变窄的内侧间隙与进入时的内收时刻显著相关。内收力矩与机械轴(内翻对齐)显著相关，与关节间隙宽度、疼痛评分呈负相关。Logistic回归分析显示，内收力矩每增加1%，膝关节OA进展的风险就增加6.46倍。结论：反映内侧间隙动态负荷的膝关节基线内收力矩可以预测6年后膝关节内侧间隙的动态负荷。
Objective: To test the hypothesis that dynamic load at baseline can predict radiographic disease progression in patients with medial compartment knee osteoarthritis (OA).Methods: During 1991-93 baseline data were collected by assessment of pain, radiography, and gait analysis in 106 patients referred to hospital with medial compartment knee OA. At the six year follow up, 74 patients were again examined to assess radiographic changes. Radiographic disease progression was defined as more than one grade narrowing of minimum joint space of the medial compartment.Results: In the 32 patients showing disease progression, pain was more severe and adduction moment was higher at baseline than in those without disease progression (n=42). Joint space narrowing of the medial compartment during the six year period correlated significantly with the adduction moment at entry. Adduction moment correlated significantly with mechanical axis (varus alignment) and negatively with joint space width and pain score. Logistic regression analysis showed that the risk of progression of knee OA increased 6.46 times with a 1% increase in adduction moment.Conclusions: The results suggest that the baseline adduction moment of the knee, which reflects the dynamic load on the medial compartment, can predict radiographic OA progression at the six year follow up in patients with medial compartment knee OA.