THE BIOLOGICAL SIGNIFICANCE OF SOLUBLE INTERLEUKIN-2 RECEPTORS IN SOLID TUMORS
THE BIOLOGICAL SIGNIFICANCE OF SOLUBLE INTERLEUKIN-2 RECEPTORS IN SOLID TUMORS
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DOI：
10.1016/0277-5379(90)90253-p
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发表时间：
1990-01-01
影响因子：
8.4
通讯作者：
TANCINI, G
中科院分区：
文献类型：
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作者：
LISSONI, P;BARNI, S;TANCINI, G
为了进一步了解可溶性IL-2受体（sIL-2 R）在实体瘤中的生物学意义，我们评估了160例癌症患者（乳腺癌40例，肺癌66例，结肠癌18例，胃癌22例，宫颈癌14例）和58例健康受试者作为对照。血清sIL-2 R的平均水平，用酶免疫测定法测定，显着高于癌症患者比对照组。转移性癌症患者的数值明显高于非转移性患者;除小细胞肺癌外，所有肿瘤组织类型的差异均具有显著性。此外，在15例患者中，sIL-2 R的评价，无论是在桡动脉手术前或后，一个显着的手术引起的sIL-2 R的平均值增加。最后，化疗诱导的sIL-2 R升高似乎与缺乏临床反应有关。提示sIL-2 R可能是实体瘤患者机体生物学反应的一个标志物，其意义有待进一步研究。
In an attempt to further understand the biological significance of soluble IL-2 receptors (sIL-2R) in solid tumors, we have evaluated 160 cancer patients (breast 40; lung: 66; colon: 18; stomach: 22; uterine cervix: 14) and 58 healthy subjects, as controls. Serum mean levels of sIL-2R, measured with an enzyme immunoassay, were significantly higher in cancer patients than in controls. Metastatic cancer patients showed significantly higher values than the non-metastatic ones; this difference was significant in all tumor histotypes, except small cell lung carcinoma. Moreover, in 15 patients in whom sIL-2R were evaluated either before or after radial sugery, a significant surgery-induced increase in sIL-R mean value was seen. Finally, the chemotherapy-induced rise in sIL-2R appeared to be associated with a lack of clinical response. These results seem to suggest that sIL-2R may be a marker of host biological response in patients with solid tumors, the significance of which needs further investigation.