Beyond superior temporal cortex: intersubject correlations in narrative speech comprehension.
Beyond superior temporal cortex: intersubject correlations in narrative speech comprehension.
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DOI：
10.1093/cercor/bhm049
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Stephen Wilson;Istvan Molnar-Szakacs;M. Iacoboni
中科院分区：
文献类型：
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作者：
Stephen Wilson;Istvan Molnar-Szakacs;M. Iacoboni
上颞叶皮层在言语理解中的作用已经确立，但在生态有效的环境中，理解语言的完整区域网络尚不清楚。在一项功能性磁共振成像（fMRI）研究中，我们向24名受试者提供了听觉或视听叙事，并使用无模型的主体间相关性分析来揭示在叙事过程中，不同受试者的大脑区域以一致的方式被调制。还进行了与静息状态的常规比较。两种分析都显示了预期的颞上区增加，然而，主体间相关分析也揭示了涉及叙事性言语理解的区域网络的扩展。其中有两个发现尤为突出。首先，“默认模式”网络中的许多区域（通常相对于休息状态失活）被听觉或视听输入的时变特性系统地调节。这些区域包括前扣带和邻近的内侧额叶皮层，后扣带和邻近的楔前叶。其次，广泛的双侧额叶下区和运动前区与听觉和视听语言理解有关。这种扩展的区域网络对于更高层次的语言过程以及与语言外认知、情感和人际系统的接口可能很重要。
The role of superior temporal cortex in speech comprehension is well established, but the complete network of regions involved in understanding language in ecologically valid contexts is less clearly understood. In a functional magnetic resonance imaging (fMRI) study, we presented 24 subjects with auditory or audiovisual narratives, and used model-free intersubject correlational analyses to reveal brain areas that were modulated in a consistent way across subjects during the narratives. Conventional comparisons to a resting state were also performed. Both analyses showed the expected recruitment of superior temporal areas, however, the intersubject correlational analyses also revealed an extended network of areas involved in narrative speech comprehension. Two findings stand out in particular. Firstly, many areas in the "default mode" network (typically deactivated relative to rest) were systematically modulated by the time-varying properties of the auditory or audiovisual input. These areas included the anterior cingulate and adjacent medial frontal cortex, and the posterior cingulate and adjacent precuneus. Secondly, extensive bilateral inferior frontal and premotor regions were implicated in auditory as well as audiovisual language comprehension. This extended network of regions may be important for higher-level linguistic processes, and interfaces with extralinguistic cognitive, affective, and interpersonal systems.