Positron emission tomography imaging in depression: a neural systems perspective
Positron emission tomography imaging in depression: a neural systems perspective
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DOI：
10.1016/s1052-5149(03)00104-7
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发表时间：
2003-11-01
影响因子：
2.3
通讯作者：
Mayberg, HS
中科院分区：
文献类型：
--
作者：
Mayberg, HS
抑郁症是一种常见的神经行为障碍，以持续的消极情绪和认知、昼夜节律和运动功能的选择性缺陷为特征。本文介绍了一个综合的功能性神经影像学研究，在数据驱动的抑郁症模型的背景下解释。在这个神经系统模型中，重度抑郁发作被认为是高度整合的边缘皮层区域网络之间的适应不良功能相互作用的净结果，这些区域通常负责在认知和躯体压力的情况下维持稳态情绪控制。抑郁症患者的发现，确定使用正电子发射断层扫描测量区域血流和代谢，在这种情况下进行了讨论，强调疾病状态和治疗的具体效果。进一步表征扫描模式变异性的策略也从识别潜在的基于成像的生物标志物的角度提出，这将有助于个体抑郁症患者的最佳治疗选择。
Depression is a common neurobehavioral disorder, characterized by persistent negative mood and selective deficits in cognitive, circadian, and motor functioning. This article presents a synthesis of functional neuroimaging studies, interpreted in the context of a data-driven depression model. In this neural systems model, a major depressive episode is considered the net result of maladaptive functional interactions among a highly-integrated network of limbic-cortical regions that are normally responsible for maintaining homeostatic emotional control in situations of cognitive and somatic stress. Findings in depressed patients, identified using positron emission tomography measures of regional blood flow and metabolism, are discussed in this context, emphasizing illness-state and treatment-specific effects. Strategies to further characterize scanpattern variability are also presented from the perspective of identifying potential imaging-based biomarkers that will facilitate optimal treatment selection in individual, depressed patients.