CORRELATION BETWEEN THE INFECTIVITY OF HEPATITIS-C VIRUS IN-VIVO AND ITS INFECTIVITY IN-VITRO
CORRELATION BETWEEN THE INFECTIVITY OF HEPATITIS-C VIRUS IN-VIVO AND ITS INFECTIVITY IN-VITRO
复制标题
DOI：
10.1073/pnas.90.13.6037
复制
发表时间：
1993-07-01
影响因子：
11.1
通讯作者：
YOSHIKURA, H
中科院分区：
文献类型：
--
作者：
SHIMIZU, YK;PURCELL, RH;YOSHIKURA, H
A murine retrovirus-infected human T-cell line, HPB-Ma, supported replication of hepatitis C virus (HCV) at least as well as the previously reported Molt4-Ma cells. Cloning of HPB-Ma cells revealed a clonal variation of cellular susceptibility to HCV infection. Using one of the sensitive clones, we tested HCV inocula from different sources for their infectivity titer in cell culture. The in vitro titers obtained correlated with the reported infectivity titers of the inocula in chimpanzees. Thus, the system appears to be useful for estimating the in vivo infectivity of HCV.
