Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies - central European experience
Human exposure to polyhalogenated hydrocarbons and incidence of selected malignancies - central European experience
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DOI：
10.4149/neo_2009_04_353
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发表时间：
2009-01-01
期刊：
影响因子：
3
通讯作者：
Trnovec, T.
中科院分区：
文献类型：
--
作者：
Bencko, V.;Rames, J.;Trnovec, T.
本文描述了两项生态学研究的结果，旨在通过比较斯洛伐克共和国国家癌症登记处和捷克共和国国家肿瘤登记处数据库中的数据，分析暴露于多氯代烃（主要是PCB和TCDD/Fs）的两个人群中选定恶性肿瘤的发病率将斯洛伐克共和国米哈洛夫采区（约500万居民）和捷克共和国（10，300万居民）的人口数据与捷克共和国Uherske Hradiste区（约112，000居民）和Uherske Hradiste区（约146，000居民）的人口数据进行比较。这些地区由于生产和工业使用多氯联苯而被确认为多氯联苯污染区，对1987-1996年10年期间的数据进行了分析。女性甲状腺、胰腺、乳腺、卵巢、膀胱和脑肿瘤的年龄校正世界标准比率（WSR），以及女性甲状腺、胰腺、乳腺、膀胱、脑肿瘤的年龄校正世界标准比率（WSR），前列腺和睾丸肿瘤的男性进行了比较。FS似乎有助于观察到的乳腺癌和前列腺癌的发病率显着降低在米哈洛夫采区和较低的膀胱癌发病率在Uherske Hradiste区。然而，已描述了羟基化和甲磺酰基PCB代谢物的抗雌激素和抗雄激素特性。这些属性可能有助于通过这些代谢物可能会调节乳腺癌，前列腺癌和膀胱cancer.The的发展机制，我们的分析结果指出，暴露于外源性物质的人群中的癌症发病率的风险评估，或更普遍的潜在问题，因为它涉及到广泛的癌症风险因素的混淆。
This paper describes results of two ecological studies design to analyze the incidence of selected malignancies in two populations exposed to polychlorinated hydrocarbons, mostly PCBs and TCDDs/Fs by comparing data available in the National Cancer Registry of the Slovak Republic and National Oncological Registry of the Czech Republic databases for the Slovak Republic (similar to 5 M inhabitants) and the Czech Republic (10,3 M inhabitants) to the data relevant for the population of Michalovce District, the Slovak Republic (similar to 112,000 inhabitants) and Uherske Hradiste, the Czech Republic (146,000 inhabitants). Those districts are recognized as PCB-contaminated areas due to production and industrial use of PCBs.Data were analyzed for the 10-year period 1987-1996. The age adjusted world standard ratio (WSR) incidence of thyroid, pancreatic, breast, ovarian, bladder, and brain tumors in females and thyroid, pancreatic, breast, bladder, brain, prostate and testicular tumors in males were compared.Neither PCBs nor TCDDs/Fs appear to contribute to the observed significantly lower incidence of breast and prostate cancer in the Michalovce District and lower bladder cancer incidence in Uherske Hradiste District. However, anti-estrogenic and anti-androgenic properties have been described for hydroxylated and methylsulfonyl PCB metabolites. These properties could contribute to a mechanism through which these metabolites might modulate the development of breast, prostate and bladder cancer.The results of our analysis points to substantial potential problems of risk assessment for cancer incidence in populations exposed to xenobiotics, or more generally, as it relates to a wide spectrum of confoundings of cancer risk factors.