Cell transplantation to the auditory nerve and cochlear duct
Cell transplantation to the auditory nerve and cochlear duct
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DOI：
10.1016/j.expneurol.2005.11.006
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发表时间：
2006-03-01
影响因子：
5.3
通讯作者：
Ito, J
中科院分区：
文献类型：
--
作者：
Sekiya, T;Kojima, K;Ito, J
我们已经开发出一种技术，可以将细胞输送到内耳，而不会损伤密封内淋巴和外淋巴腔的膜。这些膜的完整性对正常听力至关重要，该技术应显着减少细胞移植过程中的手术创伤。将胚胎干细胞移植到萎缩的听神经的内听道部分，沿其广泛沿着迁移。移植后4 - 5周，不仅在整个听神经中发现了细胞，而且在Rosenthal管和中阶中也发现了细胞，中阶是听神经系统最远端的部分，毛细胞位于中阶中。移植细胞的迁移在听神经损伤后更为广泛。在未受损的神经中，迁移更有限，但细胞显示出更多的神经元分化迹象。这突出了组织损伤和修复潜力之间的重要平衡。(c)2005年爱思唯尔公司All rights reserved.
We have developed a technique to deliver cells to the inner ear without injuring the membranes that seal the endolymphatic and perilymphatic chambers. The integrity of these membranes is essential for normal hearing, and the technique should significantly reduce surgical trauma during cell transplantation. Embryonic stem cells transplanted at the internal auditory meatal portion of an atrophic auditory nerve migrated extensively along it. Four-five weeks after transplantation, the cells were found not only throughout the auditory nerve, but also in Rosenthal's canal and the scala media, the most distal portion of the auditory nervous system where the hair cells reside. Migration of the transplanted cells was more extensive following damage to the auditory nerve. In the undamaged nerve, migration was more limited, but the cells showed more signs of neuronal differentiation. This highlights an important balance between tissue damage and the potential for repair. (c) 2005 Elsevier Inc. All rights reserved.