Depression and stages of Huntington's disease.
Depression and stages of Huntington's disease.
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DOI：
10.1176/jnp.17.4.496
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发表时间：
2005-11
期刊：
影响因子：
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通讯作者：
Jane S. Paulsen;C. Nehl;K. Hoth;J. Kanz;Michelle L. Benjamin;Rachel Conybeare;Bradley D. McDowell;B. Turner
中科院分区：
文献类型：
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作者：
Jane S. Paulsen;C. Nehl;K. Hoth;J. Kanz;Michelle L. Benjamin;Rachel Conybeare;Bradley D. McDowell;B. Turner
对患有明显亨廷顿舞蹈病（HD）的个体进行了关于抑郁症状的存在、频率和严重程度的访谈，以更好地表征亨廷顿舞蹈病在整个病程中的抑郁情绪。抑郁症的发病率是普通人群的两倍多。一半的人报告说他们曾寻求抑郁症治疗，超过10%的人报告说他们至少有过一次自杀企图。HD患者认同显著抑郁的比例随着疾病进展而减少。尽管抑郁症对公共卫生有影响，但在HD中可用的治疗方法未得到充分利用，需要研究来证明标准抑郁症治疗在这一人群中的疗效和有效性。
Individuals with manifest Huntington's disease (HD) were interviewed with regard to the presence, frequency, and severity of depression symptoms to better characterize depressed mood across the disease course in HD. Rates of depression were more than twice that found in the general population. One-half reported that they had sought treatment for depression, and more than 10% reported having at least one suicide attempt. The proportion of HD patients endorsing significant depression diminished with disease progression. Despite the public health impact of depression, available treatments are underutilized in HD, and research is needed to document the efficacy and effectiveness of standard depression treatments in this population.