EARLY NERVE REPAIR AFTER INJURY TO THE POSTGANGLIONIC PLEXUS: AN EXPERIMENTAL STUDY OF SENSORY AND MOTOR NEURONAL SURVIVAL IN ADULT RATS
EARLY NERVE REPAIR AFTER INJURY TO THE POSTGANGLIONIC PLEXUS: AN EXPERIMENTAL STUDY OF SENSORY AND MOTOR NEURONAL SURVIVAL IN ADULT RATS
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节后丛损伤后的早期神经修复：成年大鼠感觉和运动神经元存活的实验研究
DOI：
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发表时间：
2003
影响因子：
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通讯作者：
M. Wiberg
中科院分区：
文献类型：
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作者：
Jianjun Ma;L. Novikov;J. Kellerth;M. Wiberg
抽象的。臂丛神经修复的最佳时机尚有争议。在这项研究中，我们研究了早期重建外周神经营养支持是否可能减少神经元丢失。成年大鼠14只，横断C7脊神经。对所有投射到C7神经的背根神经节和脊髓运动神经元的感觉细胞进行逆行标记。然后，C7神经的近端和远端通过一期修复或带血管的或传统的尺神经移植物重新吻合。术后16周，神经修复明显减少了C7感觉和运动神经元的丢失。最引人注目的是，对照组30%的运动神经元丢失通过早期神经修复几乎消除。在移植的动物中，一半存活的神经元通过移植再生，与带血管的神经移植和传统神经移植没有区别。这些结果表明，早期手术干预可能促进臂丛神经损伤后神经元的存活和再生。
Abstract. The optimal time for brachial plexus nerve repair is debatable. In this study we examined whether early re-establishment of neurotrophic support from the periphery might reduce neuronal loss. In 14 adult rats, the C7 spinal nerve was transsected. All sensory cells of the dorsal root ganglion and spinal motor neurons projecting into the C7 nerve were labelled retrogradely. The proximal and distal portions of the C7 nerve were then reanastomosed by either primary repair or by a vascularised or conventional ulnar nerve graft. At 16 weeks postoperatively, the nerve repair had significantly reduced the loss of both sensory and motor C7 neurons. Most striking was that a 30% motor neuronal loss in the control was almost eliminated by early nerve repair. In the grafted animals, half of the surviving neurons had regenerated through the graft, with no difference between vascularised and conventional nerve grafts. These results suggest that early surgical intervention may promote neuronal survival and regeneration after injuries to the brachial plexus.
在 IGF 支持的神经再生过程中，坐骨神经中胰岛素样生长因子 (IGF) 基因表达升高。
DOI：
10.1016/0169-328x(94)90162-7
发表时间：
1994
期刊：
Brain research. Molecular brain research
影响因子：
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作者：
Glazner,GW;Morrison,AE;Ishii,DN
通讯作者：
Ishii,DN