Endogenous zinc in neurological diseases.
Endogenous zinc in neurological diseases.
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DOI：
10.3988/jcn.2005.1.2.121
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发表时间：
2005-10
期刊：
影响因子：
--
通讯作者：
Koh JY
中科院分区：
文献类型：
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作者：
Koh JY
公元前 2000 年的埃及纸莎草纸（例如史密斯纸莎草纸）中就提到了锌在药用护肤霜中的使用，而且锌显然在整个罗马和现代时期得到了相当稳定的使用（例如，美国洗剂以其锌矿石命名为“炉甘石”）。因此，具有讽刺意味的是，锌是生物学和医学信号离子万神殿中相对较晚的成员。然而，锌的大量生物学功能、健康影响和药理学靶标的出现表明，它可能成为“二十一世纪的钙”。这里总结了内源性锌的神经生物学作用。
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout Roman and modern times (for example, as the American lotion named for its zinc ore, 'Calamine'). It is, therefore, somewhat ironic that zinc is a relatively late addition to the pantheon of signal ions in biology and medicine. However, the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'. Here neurobiological roles of endogenous zinc is summarized.