In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.
In vivo quantification of cochlin in glaucomatous DBA/2J mice using optical coherence tomography.
复制标题
使用光学相干断层扫描对青光眼 DBA/2J 小鼠中的耳蜗蛋白进行体内定量。
DOI：
10.1038/srep11092
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发表时间：
2015
影响因子：
4.6
通讯作者：
Bhattacharya,SanjoyK
中科院分区：
文献类型：
--
作者：
Wang,Jianhua;Aljohani,Ayman;Carreon,Teresia;Gregori,Giovanni;Bhattacharya,SanjoyK
在DBA/2 J小鼠中，小梁网（TM）中cochlin的表达先于临床青光眼症状。在局部组织（TM）中定量cochlin的能力提供了潜在的诊断和预后价值。我们提出了两个（光谱和磁动）光学相干断层扫描（OCT）的方法在体内cochlin定量在一个周期性的方式。如在注射后3.5小时所见，cochlin抗体OCT信号保持稳定长达24小时，从而允许在活小鼠眼中重复定量。
The expression of cochlin in the trabecular meshwork (TM) precedes the clinical glaucoma symptoms in DBA/2J mice. The ability to quantify cochlin in the local tissue (TM) offers potential diagnostic and prognostic values. We present two (spectroscopic and magnetomotive) optical coherence tomography (OCT) approaches forin vivocochlin quantification in a periodic manner. The cochlin-antibody OCT signal remains stable for up to 24 hours as seen at 3.5 hours after injection allowing for repeated quantification in the living mouse eyes.