Infection of mice with Francisella as an immunological model.
Infection of mice with Francisella as an immunological model.
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DOI：
10.1002/0471142735.im1914s93
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发表时间：
2011-04-01
影响因子：
--
通讯作者：
Elkins, Karen L
中科院分区：
文献类型：
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作者：
Conlan, J Wayne;Chen, Wangxue;Elkins, Karen L
本单元描述了各种小鼠感染模型的实用性，用于研究致病机理和对兼性胞内细菌病原体土拉弗朗西斯菌的适应性免疫反应。通过明智地使用不同的小鼠和细菌菌株的组合，以及不同的感染途径，小鼠兔热病模型可用于探索F。土拉菌感染和免疫。此外，使用弗朗西斯菌属，特别是活疫苗株（LVS）的研究，作为一个方便和易于处理的模型系统，似乎是代表哺乳动物宿主对细胞内病原体的反应一般。
This unit describes the utility of various mouse models of infection for studying pathogenesis and adaptive immune responses to the facultative intracellular bacteria pathogen Francisella tularensis. By judicious use of different combinations of mouse and bacterial strains, as well as different routes of infection, murine tularemia models may be used to explore a complete picture of F. tularensis infection and immunity. Moreover, studies using Francisella, particularly the Live Vaccine Strain (LVS), serve as a convenient and tractable model system that appears to be representative of mammalian host responses to intracellular pathogens in general.