PRIMAQUINE-INDUCED CHANGES IN MORPHOLOGY OF EXOERYTHROCYTIC STAGES OF MALARIA
PRIMAQUINE-INDUCED CHANGES IN MORPHOLOGY OF EXOERYTHROCYTIC STAGES OF MALARIA
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DOI：
10.1126/science.160.3833.1233
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发表时间：
1968-01-01
期刊：
影响因子：
56.9
通讯作者：
AIKAWA, M
中科院分区：
文献类型：
--
作者：
BEAUDOIN, RL;AIKAWA, M
暴露于伯氨喹 48 小时，会导致在源自火鸡胚胎脑的培养细胞中生长的法拉克斯疟原虫的红细胞外阶段发生病变。在光学显微镜下观察时，病变以细胞质空泡的形式出现。电子显微镜显示这些液泡是肿胀的线粒体，很容易通过其典型的原生动物嵴来识别。宿主细胞的线粒体不受影响。
Exposure to primaquine for 48 hours caused lesions in the exoerythrocytic stages ofPlasmodium fallaxgrown in cultivated cells derived from embryonic turkey brain. The lesions appeared in the form of cytoplasmic vacuoles when viewed under the light microscope. The electron microscope revealed these vacuoles as swollen mitochondria readily identifiable by their typical protozoan cristae. Mitochondria of the host cell were unaffected.