Isolation, tactile startle and resting blood pressure in Long-Evans rats.
Isolation, tactile startle and resting blood pressure in Long-Evans rats.
复制标题
Long-Evans 大鼠的隔离、触觉惊吓和静息血压。
DOI：
10.1016/0031-9384(88)90215-6
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发表时间：
1988
影响因子：
2.9
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Woodworth,CH;Johnson,AK
社会隔离的影响，包括个人住房在标准条件下的动物园，并施加在90天以上的雄性大鼠，触觉惊吓反应，伤害性，静息心率和动脉血压，以及这些变量之间的相互关系进行了评估。触觉惊吓受刺激强度，重复试验和测试时间相对于光/暗周期，但不受社会隔离1至29天。热板潜伏期不受个人住房从12至43天。血压和心率与隔离9至58天呈负相关，随着隔离天数的增加显着下降。虽然不直接受隔离，触觉惊吓的影响，其次由个人住房产生的血压差异。静息压较低的大鼠对低强度惊吓刺激作出反应，而高压力的大鼠对低强度惊吓刺激无效，表明阈值差异，并提出血压调节感觉反应的假设。
The effect of social isolation, consisting of individual housing in the vivarium under standard conditions and imposed on male rats older than 90 days, was assessed on tactile startle reactivity, nociception, resting heart rate and arterial blood pressure, and on intercorrelations among these variables. Tactile startle was affected by stimulus intensity, repeated trials and time of testing relative to the light/dark cycle, but not by social isolation from 1 to 29 days. Hot-plate latency was not affected by individual housing from 12 to 43 days. Blood pressure and heart rate were negatively correlated with isolation from 9 to 58 days, showing a significant decline over increasing days of isolation. Although not affected directly by isolation, tactile startle was affected secondarily by differences in blood pressure produced by individual housing. Rats with lower resting pressures responded to low-intensity startle stimuli that were not effective in rats with higher pressures, indicating a threshold difference and suggesting the hypothesis that blood pressure acts to modulate sensory reactivity.