fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis
fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis
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DOI：
10.1080/mmy.40.3.259.262
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发表时间：
2002-06-01
期刊：
影响因子：
2.9
通讯作者：
Stevens, DA
中科院分区：
文献类型：
--
作者：
Clemons, KV;Miller, TK;Stevens, DA
在真菌中，双组分组氨酸激酶具有多种功能，包括调节细胞膜敏感性和细胞壁组装。此外，这些蛋白质之一，cos-1，已被证明是重要的白色念珠菌的毒力。最近，一个假定的组氨酸激酶，fos-1，已被分离和部分特征，从烟曲霉。在这里，我们比较了一个fos-1缺失菌株与亲本野生型菌株在系统性曲霉菌病小鼠模型的毒力。我们的研究结果表明，与亲本野生型菌株相比，fos-1缺失菌株的毒力显著降低。因此，我们认为fos-1双组分组氨酸激酶是A.烟熏。
In fungi, two-component histidine kinases have various functions including regulation of osmosensitivity, and of cell-wall assembly. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Recently, a putative histidine kinase, fos-1, has been isolated and partially characterized from Aspergillus fumigatus. Here we compare the virulence of a fos-1 deletion strain with that of the parental wild-type strain in a murine model of systemic aspergillosis. Our results show that the fos-1 deletion strain has significantly reduced virulence as compared with the parental wild-type strain. Thus, we propose that the fos-1 two-component histidine kinase is a virulence factor of A. fumigatus.