Beta Carotene Therapy for Erythropoietic Protoporphyria and Other Photosensitivity Diseases
Beta Carotene Therapy for Erythropoietic Protoporphyria and Other Photosensitivity Diseases
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β-胡萝卜素治疗红细胞生成性原卟啉症和其他光敏性疾病
DOI：
10.1001/archderm.1977.01640090077011
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发表时间：
1977
影响因子：
--
通讯作者：
E. Kass
中科院分区：
文献类型：
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作者：
M. Mathews;M. Pathak;T. Fitzpatrick;L. Harber;E. Kass
·我们使用大剂量的β-胡萝卜素(Solatene)(每天15-180 mg)治疗133名红细胞生成性原卟啉(EPP)患者、27名多形性光疹患者、6名日光性荨麻疹患者、3名再障水症患者、1名迟发性皮肤卟啉患者和2名光化网状疾病患者，以缓解与这些疾病相关的光敏反应。84%的红细胞生成性原卟啉症患者对阳光的耐受能力增加了3倍或更多。另一方面，只有9名患有多形性光疹的患者和五分之一接受其他形式光敏治疗的患者表现出类似的改善。我们的结论是，β胡萝卜素是治疗EPP的有效方法，但其他形式的光敏性需要用β胡萝卜素进行经验治疗研究，以确定这种化合物在EPP以外的条件下的有效性范围(如果有的话)。(Arch Dermatol 113：1229-1232,1977)
• We treated with high doses of oral beta carotene (Solatene) (15 to 180 mg/ day) 133 patients suffering from erythropoietic protoporphyria (EPP), 27 patients with polymorphous light eruption, six patients with solar urticaria, three patients with hydroa aestivale, one patient with porphyria cutanea tarda, and two patients with actinic reticuloid to relieve the photosensitivity associated with these diseases. Eighty-four percent of the patients with erythropoietic protoporphyria increased by a factor of 3 or more their ability to tolerate sunlight. On the other hand, only nine of the patients with polymorphous light eruption, and one fifth of the patients with all of the other forms of photosensitivity treated showed similar improvement. We conclude that beta carotene is an effective treatment for EPP, but that other forms of photosensitivity will need empirical therapeutic study with beta carotene to determine the range of effectiveness, if any, of this compound in conditions other than EPP. ( Arch Dermatol 113:1229-1232, 1977