Age-related difference in pulmonary response to ozone.
Age-related difference in pulmonary response to ozone.
复制标题
肺部对臭氧反应的年龄相关差异。
DOI：
10.1016/0005-2728(87)90028-4
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Balis,JU
中科院分区：
文献类型：
--
作者：
Montgomery,MR;Raska-Emery,P;Balis,JU
急性暴露于1.5ppm的O3在成年和老年大鼠肺产生不同的反应。总三磷酸核苷酸在成年动物中仅略有减少，但在老年动物中显著减少。此外，与老年动物相比，成年动物保持了更大比例的还原形式（NADPH）的可用三磷酸核苷酸。这些结果表明，老年动物可能无法维持肺还原当量有效地作为成年动物在面对氧化剂的侮辱。
Acute exposure to 1.5 ppm O3produced different responses in adult and aged rat lungs. Total triphosphonucleotides were only slightly decreased in adult animals, but were markedly decreased in aged animals. Also, adult animals maintained a greater proportion of their available triphosphonucleotides in the reduced form (NADPH) compared to aged animals. These results suggest that aged animals may not be able to maintain pulmonary reducing equivalents as efficiently as adult animals in the face of an oxidant insult.