High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine
High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine
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DOI：
10.1002/jgm.930
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发表时间：
2006-08
期刊：
影响因子：
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通讯作者：
M. Tada;E. Hatano;K. Taura;T. Nitta;Naoki Koizumi;I. Ikai;Y. Shimahara
中科院分区：
文献类型：
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作者：
M. Tada;E. Hatano;K. Taura;T. Nitta;Naoki Koizumi;I. Ikai;Y. Shimahara
通过尾静脉流体动力注射裸质粒 DNA (pDNA) 是将基因转移到肝脏的安全有效的方法。然而，基因转移对于肝细胞癌（HCC）的治疗尚未取得成功。因此，我们研究了在二乙基亚硝胺（DEN）诱导的大鼠肝癌模型中通过尾静脉和肝动脉进行水动力注射的可行性和有效性。
Hydrodynamic injection of naked plasmid DNA (pDNA) via the tail vein is a safe and effective method of gene transfer to the liver. However, successful gene transfer has yet to be shown for hepatocellular carcinoma (HCC); therefore, we investigated the feasibility and efficacy of hydrodynamic injection via the tail vein and hepatic artery in a diethylnitrosamine (DEN)‐induced HCC model in rats.