Conditioned effects of kindling
Conditioned effects of kindling
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DOI：
10.1016/s0149-7634(01)00054-9
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发表时间：
2001-12-01
影响因子：
8.2
通讯作者：
Pinel, JPJ
中科院分区：
文献类型：
--
作者：
Barnes, SJ;Pinel, JPJ
对许多大脑部位中的任何一个进行轻度周期性电刺激都会导致诱发运动性癫痫发作的发展和进行性强化。自1969年发现以来，这种点燃现象已被广泛研究，作为癫痫发生的模型和神经可塑性的一种形式，最近越来越多的兴趣点燃作为伴随某些形式的癫痫发作间期（即癫痫发作之间）情绪变化的模型。尽管广泛使用的点燃模型，很少考虑到所发挥的作用，经常与交付的点燃刺激的线索。然而，我们最近已经证明，与标准点燃协议（如刺激环境）相关的线索产生条件性影响的运动性癫痫发作和发作间期行为的大鼠和一些点燃网站，如杏仁核，产生条件性发作间期行为的防御性质。这些研究结果的影响，特别是发作间期的行为变化的研究和点燃研究一般进行了讨论。(C)2002爱思唯尔科技有限公司版权所有。
Mild periodic electrical stimulation to any one of many brain sites leads to the development and progressive intensification of elicited motor seizures. Since its discovery in 1969, this kindling phenomenon has been widely studied both as a model of epileptogenesis and as a form of neuroplasticity, and recently there has been increasing interest in kindling as a model of the interictal (i.e. between-seizures) changes in emotionality that accompany certain forms of epilepsy. Despite the extensive use of the kindling model, little consideration has been given to the role played by the cues regularly associated with the delivery of the kindling stimulations. However, we have recently demonstrated that cues associated with the standard kindling protocol (e.g. the stimulation environment) produce conditioned effects on both the motor seizures and interictal behavior of rats and that some kindling sites, such as the amygdala, produce conditioned interictal behaviors that are defensive in nature. The implications that these findings have for the study of interictal behavioral changes in particular and to kindling research in general are discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.