Genetic linkage in schizophrenia: perspectives from genetic epidemiology.
Genetic linkage in schizophrenia: perspectives from genetic epidemiology.
复制标题
精神分裂症的遗传联系：遗传流行病学的观点。
DOI：
10.1093/schbul/15.3.453
复制
发表时间：
1989
影响因子：
6.6
通讯作者：
Gottesman,II
中科院分区：
文献类型：
--
作者：
McGue,M;Gottesman,II
精神分裂症的遗传流行病学研究进行了简要和选择性的审查。精神分裂症的以下三个显著特征对连锁研究的设计提出了挑战：（1）对双生子和家系数据的分析始终未能确定单个主基因对精神分裂症风险的影响;（2）确定多重家系并不能保证对主基因分离的家系进行抽样，即使主基因效应存在;和（3）环境影响似乎在至少某些形式的精神分裂症的病因学中起重要作用。这些功能的影响，在精神分裂症连锁研究的设计进行了讨论。
Research on the genetic epidemiology of schizophrenia is briefly and selectively reviewed. The following three salient features of schizophrenia that represent challenges to the design of linkage studies are identified: (1) The analysis of twin and family data has consistently failed to identify a single major gene effect upon schizophrenia risk; (2) the ascertainment of multiplex families does not guarantee the sampling of families who are segregating for the major gene even if a major gene effect exists; and (3) environmental influences appear to play an essential role in the etiology of at least some forms of schizophrenia. The implications of these features for the design of linkage studies in schizophrenia are discussed.