PRODUCTION OF INTERFERONS AND LYMPHOKINES IN LEUKOCYTE-CULTURES OF PATIENTS WITH SCHIZOPHRENIA
PRODUCTION OF INTERFERONS AND LYMPHOKINES IN LEUKOCYTE-CULTURES OF PATIENTS WITH SCHIZOPHRENIA
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DOI：
10.1016/0920-9964(94)00046-b
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发表时间：
1995-05-01
影响因子：
4.5
通讯作者：
KIRCHNER, H
中科院分区：
文献类型：
--
作者：
HORNBERG, M;AROLT, V;KIRCHNER, H
最近，一些证据表明，免疫功能障碍可能在精神分裂症的发病机制中起作用。因此，我们在37名精神分裂症患者(DSM-III-R)和42名健康献血员的全血检测中，研究了在有丝分裂或病毒刺激下产生干扰素和淋巴因子的能力。用植物血凝素(PHA)诱导白介素2(IL-2)、干扰素-γ(干扰素-γ)、白介素6(IL-6)、可溶性白介素2受体(sIL-2R)和新城疫病毒(NDV)诱导干扰素α(2)。用双抗体夹心法测定血清中所有淋巴因子及sIL-2R。精神科医生根据国际公认的标准对患者的精神病理状态进行评估。患者组表现出干扰素α(2)和γ水平降低的趋势，IL-2的产生显著减少。精神分裂症患者血清sIL-2R水平明显升高。后者的增加与较差的预后评估有关(Strauss和Carpenter)。这种联系似乎令人感兴趣。然而，由于不能进行纵向研究，它的意义还不被理解。
Recently, several lines of evidence have suggested the possibility of immunological dysfunction in the pathogenesis of schizophrenia. We therefore investigated the ability to produce interferons and lymphokines in response to mitogenic or viral stimulation in a whole blood assay of 37 schizophrenic patients (DSM-III-R) and of 42 healthy blood donors. Phytohaemagglutinin (PHA) was used for the induction of interleukin-2 (IL-2), interferon gamma (IFN gamma), interleukin-6 (IL-6) and the soluble interleukin-2 receptor (sIL-2R) and Newcastle Disease Virus (NDV) for the induction of interferon alpha(2) (IFN alpha(2)). All lymphokines and, in addition, the sIL-2R in the sera were determined by ELISA technique. The psychopathological status of the patients was assessed by psychiatrists according to internationally accepted standards. The patient group showed a trend to lower levels of the interferons alpha(2) and gamma and a significant decrease of IL-2 production. The sIL-2R levels were significantly increased in the sera of schizophrenic patients. The latter increase was associated with a poor assessment of prognosis (Strauss and Carpenter). This association appears to be of interest. However, its significance is not understood, since longitudinal studies could not be performed.