Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke
Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke
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DOI：
10.1179/016164109x12608733393755
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发表时间：
2010-09-01
影响因子：
1.9
通讯作者：
Katayama, Yasuo
中科院分区：
文献类型：
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作者：
Katsumata, Toshiya;Otori, Tatsuo;Katayama, Yasuo
目的：我们探讨非糖尿病缺血性卒中患者的胰岛素抵抗与脑白质病变严重程度之间是否存在相关性。方法：研究对象为连续 105 名因非心源性卒中住院的非糖尿病患者。通过胰岛素抵抗稳态模型评估（HOMA-IR）来评估胰岛素抵抗。通过脑部MRI评估脑室周围高信号（PVH）和深部和皮质下白质高信号（DSWMH）的程度。 HOMA-IR值>=2.5表示胰岛素抵抗。结果：PVH和DSWMH的存在率分别为86.7%和83.8%。胰岛素抵抗的比例随着PVH和DSWMH等级的升高而增加。 3级PVH的HOMA-IR水平显着高于0级和1级。3级DSWMH的HOMA-IR水平显着高于0-2级。多元线性回归分析显示HOMA-IR与PVH或DSWMH显着相关。结论：发现非糖尿病合并非心源性缺血性脑卒中患者中胰岛素抵抗与脑白质病变相关。
Objective: We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.Methods: The subjects were 105 consecutive patients without diabetes who were hospitalized due to non-cardioembolic stroke. The insulin resistance was evaluated by a homeostasis model assessment of insulin resistance (HOMA-IR). The degrees of periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DSWMH) were evaluated by the brain MRI. The HOMA-IR values >= 2.5 were indicative of the insulin resistance.Results: The presence of PVH and DSWMH were 86.7 and 83.8%, respectively. The ratio of insulin resistance increased with higher grades of PVH and DSWMH. The HOMA-IR level in grade 3 PVH was significantly higher than those in grades 0 and 1. The HOMA-IR level in grade 3 DSWMH was significantly higher than those in grades 0-2. Multiple linear regression analysis showed that HOMA-IR was significantly associated with PVH or DSWMH.Conclusion: It was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke.