Memory impairment in a simple recall task increases mortality at 10 years in non-demented elderly
Memory impairment in a simple recall task increases mortality at 10 years in non-demented elderly
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DOI：
10.1002/gps.2512
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发表时间：
2011-02-01
影响因子：
4
通讯作者：
Vega, Saturio
中科院分区：
文献类型：
--
作者：
Villarejo, Alberto;Bermejo-Pareja, Felix;Vega, Saturio
目的：为了评估是否记忆障碍检测到的三个字的延迟回忆任务的迷你精神状态检查（MMSE）增加的风险mortality.Methods：的NEDICES（神经系统疾病在西班牙中部）队列研究，是一个人口普查为基础的研究，旨在检测年龄相关的神经系统疾病的人年龄在65岁及以上，生活在一个农村和两个城市社区在西班牙中部。基线时患有痴呆或无MMSE评估的参与者被排除在外。在入组后10.67年评价死亡率。采用考克斯比例风险回归模型，根据MMSE（评分0-3）中包含的三个单词延迟回忆任务的表现，对潜在协变量（性别、年龄、教育水平和合并症）进行调整，评估死亡风险。生存估计使用Kaplan-Meier方法。结果：最终的研究人群包括3778名非痴呆老年受试者。在调整混杂协变量后，记忆力最低的人（0）的死亡率比记忆力最高的人（3）高52%。风险比（HR）显示死亡率从最高到最低记忆分数呈增加趋势，这在没有（HR = 1.52; CI = 1.27-1.80）或一个（HR= 1.24; CI = 1.04-1.48）单词回忆的组中具有统计学显著性。年龄较大，男性，和合并症也与死亡率，但教育水平是不是.Conclusions：记忆障碍在三个字的延迟自由回忆，一个非常简单的任务，由世界各地的医生，增加了非痴呆老年人在10年的死亡率的风险。版权所有（C）2010约翰威利父子有限公司
Objective: To evaluate whether memory impairment detected in the three-word delayed recall task of the Mini-Mental State Examination (MMSE) increases the risk of mortality.Methods: The NEDICES (Neurological Diseases in Central Spain) cohort study, is a population census-based study, aimed at detecting age-associated neurological diseases in people aged 65 and over, living in one rural and two urban communities in central Spain. Participants with dementia or without MMSE evaluation at baseline were excluded. Mortality was evaluated 10.67 years after enrolment. Cox's proportional hazards regression models were used to evaluate the hazard of death according to performance in the three-word delayed recall task included in the MMSE (score 0-3), adjusting for potential covariates (sex, age, level of education, and comorbidity). Survival was estimated using Kaplan-Meier method.Results: The final study population comprised 3778 non-demented elderly subjects. After adjusting for confounding covariates, mortality was 52% greater in persons with the lowest memory score (0) vs. persons with the highest score (3). Hazard ratios (HR) showed a tendency to an increase in mortality from the highest to the lowest memory score, which was statistically significant for the groups with none (HR = 1.52; CI = 1.27-1.80) or one (HR= 1.24; CI = 1.04-1.48) word recall. Older age, male sex, and comorbidity were also associated with mortality, but level of education was not.Conclusions: Memory impairment in the three-word delayed free recall, a very simple task used by physicians worldwide, increases the risk of mortality at 10 years in non-demented elderly. Copyright (C) 2010 John Wiley & Sons, Ltd.