Expanded Prostate Cancer Index Composite Versus Incontinence Symptom Index and Sexual Health Inventory for Men to Measure Functional Outcomes After Prostatectomy
Expanded Prostate Cancer Index Composite Versus Incontinence Symptom Index and Sexual Health Inventory for Men to Measure Functional Outcomes After Prostatectomy
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DOI：
10.1016/j.juro.2009.02.155
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发表时间：
2009-07-01
影响因子：
6.6
通讯作者：
Wood, David P., Jr.
中科院分区：
文献类型：
--
作者：
Hedgepeth, Ryan C.;Labo, Jessica;Wood, David P., Jr.
目的：评估前列腺癌治疗后的生活质量结果很重要，因为不同的治疗提供了相似的生存结果。各种各样的生活质量调查使用的领域特定和广泛的领域工具之间的未知的相关性。我们将扩展前列腺癌综合指数（一种广泛领域的工具）的泌尿和性结局指标与男性失眠症状指数和性健康量表（领域特异性工具）的泌尿和性结局指标进行了比较。共有640名在我们机构接受根治性前列腺切除术的患者完成了扩展前列腺癌综合指数，性功能障碍症状指数和男性性健康调查问卷。比较匹配的功能结构域并计算相关系数。进行亚组分析，比较具体的信息有关恢复从尿道切除术。结果：尿失禁的措施之间的相关性为0.26至0.84，而性功能的指标为0.70至0.84。亚组分析比较刺激性症状的措施表现出较弱的相关性。在患者报告没有性活动的分析也显示出显着较低的相关性的分数比患者报告sexualactivity.Conclusions：扩展前列腺癌指数综合评分一般表现出较强的相关性与相应的Inflammatory症状指数和性健康量表的男性分数，表明类似的测量信息。刺激性评分与性生活不活跃男性评分之间的差异性相关性可能表明，扩展前列腺癌综合指数在这一人群中具有更好的描述性效度。更广泛地使用一个单一的广泛领域的工具，如扩展的前列腺癌综合指数，以评估前列腺癌治疗后的结果可能会提高临床效率，并允许在未来的治疗类型的生活质量比较研究。
Purpose: Evaluating quality of life outcomes following prostate cancer treatment is important because different treatments provide similar survival outcomes. A wide variety of quality of life surveys are used with an unknown correlation between domain specific and broad domain instruments. We compared the urinary and sexual outcome measures of the Expanded Prostate Cancer Index Composite, a broad domain instrument, to those of the Incontinence Symptom Index and the Sexual Health Inventory for Men, which are domain specific instruments.Materials and Methods: A total of 640 patients undergoing radical prostatectomy at our institution completed a combination of the Expanded Prostate Cancer Index Composite, Incontinence Symptom Index and Sexual Health Inventory for Men questionnaires. Matching functional domains were compared and correlation coefficients were calculated. Subgroup analysis was performed to compare specific information pertinent to recovery from prostatectomy.Results: Correlations between measures of incontinence were 0.26 to 0.84, while indicators of sexual function were 0.70 to 0.84. Subgroup analysis comparing measures of irritative symptoms demonstrated weaker correlations. Analysis in patients reporting no sexual activity also showed a significantly lower correlation of scores than that in patients reporting sexual activity.Conclusions: Expanded Prostate Cancer Index Composite scores generally demonstrate strong correlations with corresponding Incontinence Symptom Index and Sexual Health Inventory for Men scores, indicating similar measurements of information. Divergent correlations between irritative scores as well as scores in men who are not sexually active may indicate that the Expanded Prostate Cancer Index Composite has more descriptive validity in this population. Wider use of a single broad domain instrument such as the Expanded Prostate Cancer Index Composite to assess outcomes after prostate cancer treatment may improve clinical efficiency and allow comparative quality of life research across treatment types in the future.