Miniature intravascular photoacoustic endoscopy with coaxial excitation and detection
Miniature intravascular photoacoustic endoscopy with coaxial excitation and detection
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DOI：
10.1002/jbio.202200269
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发表时间：
2023-01-15
影响因子：
2.8
通讯作者：
Lam，Kwok-ho
中科院分区：
文献类型：
--
作者：
Lin，Riqiang;Zhang，Qi;Lam，Kwok-ho
近年来的研究指出，动脉外膜的炎症程度可能与动脉粥样硬化斑块的严重程度相关。血管内光声内窥镜可以提供动脉形态、斑块成分等信息，甚至可以检测炎症。然而，大多数报告的工作使用了非同轴配置的光声导管设计，这形成了有限的光-声重叠区域用于成像，从而错过了外膜信息。在这里，我们开发了一种新型的0.9 mm直径血管内光声导管，具有同轴激励和检测功能，以解决上述问题。成功制造了中心具有0.18 mm直径孔口的微型中空超声换能器。为了显示我们设计的意义和优点，在同轴和非同轴导管上进行了体模和离体成像实验以进行比较。结果表明，同轴导管从内膜到外膜表现出更好的光声/超声成像性能。
Recent research pointed out that the degree of inflammation in the adventitia could correlate with the severity of atherosclerotic plaques. Intravascular photoacoustic endoscopy can provide the information of arterial morphology and plaque composition, and even detecting the inflammation. However, most reported work used a noncoaxial configuration for the photoacoustic catheter design, which formed a limited light‐sound overlap area for imaging so as to miss the adventitia information. Here we developed a novel 0.9 mm‐diameter intravascular photoacoustic catheter with coaxial excitation and detection to resolve the aforementioned issue. A miniature hollow ultrasound transducer with a 0.18 mm‐diameter orifice in the center was successfully fabricated. To show the significance and merits of our design, phantom and ex vivo imaging experiments were conducted on both coaxial and noncoaxial catheters for comparison. The results demonstrated that the coaxial catheter exhibited much better photoacoustic/ultrasound imaging performance from the intima to the adventitia.