THE TRANSFER OF POLYSTYRENE MICROSPHERES FROM THE GASTROINTESTINAL-TRACT TO THE CIRCULATION AFTER ORAL-ADMINISTRATION IN THE RAT
THE TRANSFER OF POLYSTYRENE MICROSPHERES FROM THE GASTROINTESTINAL-TRACT TO THE CIRCULATION AFTER ORAL-ADMINISTRATION IN THE RAT
复制标题
DOI：
10.1111/j.2042-7158.1995.tb06714.x
复制
发表时间：
1995-07-01
影响因子：
3.3
通讯作者：
KESWICK, M
中科院分区：
文献类型：
--
作者：
EYLES, J;ALPAR, HO;KESWICK, M
本文研究了平均粒径为0.87 μ m的乳胶微球从胃肠道（GIT）向循环系统转移的有关因素，当作为悬浮载体的水的体积增加时，出现的速度和颗粒的数量增加。这可能是由于屏障细胞的完整性受到损害，从而增强了颗粒穿过肠上皮细胞的运动。水流将颗粒扫入这些通道。液体的张力很重要，因为等渗和高渗盐水在转移颗粒方面不如水有效。颗粒从邻近胃的GIT节段转移，这可以部分解释颗粒在循环中的快速出现。颗粒摄取被细胞松弛素B阻断，这表明活性组分也可能参与其中。
Factors relating to the transfer of latex microspheres of 0.87 mu m mean diameter from the gastrointestinal tract (GIT) to the circulation have been investigated.The rapidity of appearance and the number of particles increased when the volume of water used as a suspending vehicle was increased. This was probably due to barrier cell integrity being compromised so that the movement of particles across the enterocytes would be enhanced. Particles were swept into these channels by the waterflow. The tonicity of the fluid was important as isotonic and hypertonic saline were not as affective as water in transferring particles. Particles were transferred from GIT segments adjacent to the stomach which may in part explain the rapid appearance of particles in the circulation. Particle uptake was blocked by cytochalasin B which suggests an active component may also be involved.