Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.
Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT.
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使用动态 SPECT 对冠状动脉闭塞患者进行侧支循环支持的冠状动脉盗血定量特征。
DOI：
10.1109/nssmic.2014.7430923
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gullberg,GrantT
中科院分区：
文献类型：
--
作者：
Shrestha,Uttam;Botvinick,EliasH;Yeghiazarians,Yerem;Seo,Youngho;Gullberg,GrantT
冠状动脉窃血 (CS) 是一种生理过程，由于血液重新分布远离侧支依赖型心肌，导致冠状动脉血管舒张期间，侧支心肌中的血流相对于静息血流绝对减少。尽管几十年来，CS 已广为人知，但定量预测 CS 存在的人体无创灌注研究却很少。在本研究中，我们表明，使用动态单光子发射计算机断层扫描（SPECT）定量测量局部心肌血流量（MBF）和冠状动脉血流储备（CFR）的绝对值可以帮助估计冠状动脉和侧支循环阻塞的心肌中CS的存在。
Coronary steal (CS) is a physiological process that induces absolute decrease in blood flow in collateralized myocardium compared to resting flow during coronary vasodilation due to redistribution of blood away from collateral-dependent myocardium. Although, CS has been well known for decades, there are very few noninvasive perfusion studies in humans that quantitatively predict the existence of CS. In this study, we show that the quantitative measurement of absolute value of regional myocardial blood flow (MBF) and coronary flow reserve (CFR) using dynamic single photon emitted computed tomography (SPECT) can help estimate the presence of CS in myocardium with obstructed coronary artery and collateral circulation.