Role of infection in the development and exacerbation of asthma.
Role of infection in the development and exacerbation of asthma.
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DOI：
10.1586/ers.09.60
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发表时间：
2010-02
影响因子：
3.9
通讯作者：
Denlinger LC
中科院分区：
文献类型：
--
作者：
Guilbert TW;Denlinger LC
呼吸道感染与所有年龄段的喘息性疾病有关，也可能影响哮喘的发展和严重程度。由病毒、衣原体或支原体引起的呼吸道感染被认为在哮喘的发病机制中具有重要作用。在建立这些药物可引起急性喘息并影响哮喘病理生理的机制方面正在取得进展。宿主因素可能导致哮喘发病和恶化的风险，而且这些因素在早发性疾病和成年性疾病方面也可能有所不同。这篇综述讨论了与哮喘的发展和恶化有关的这些不同的联系。
Respiratory infections are associated with wheezing illnesses in all ages and may also impact the development and severity of asthma. Respiratory tract infections caused by viruses, Chlamydophila or Mycoplasma have been hypothesized to have significant roles in the pathogenesis of asthma. Progress is being made toward establishing the mechanisms by which these agents can cause acute wheezing and impact the pathophysiology of asthma. Host factors probably contribute to the risk of asthma inception and exacerbation, and these contributions may also vary with respect to early- versus adult-onset disease. This review discusses these various associations as they pertain to the development and exacerbation of asthma.