Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia
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DOI：
10.1002/ajmg.b.30181
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发表时间：
2005-07-05
影响因子：
2.8
通讯作者：
Thaker, GK
中科院分区：
文献类型：
--
作者：
Hong, LE;Wonodi, I;Thaker, GK
先前的一项研究表明，在日本样本中，二氢嘧啶酶相关蛋白2 （DRP-2）基因的*2236T > C等位基因多态性与精神分裂症之间存在关联[Nakata et al. (2003)；生物精神病学[j]。DRP-2是指导神经元发育的重要分子，其基因位于8p21染色体区域，该染色体区域先前被证明与精神分裂症和精神分裂症的几种缺陷症状有显著联系。我们比较了精神分裂症患者（n = 117）和非精神分裂症患者（n = 72）之间DRP-2 *2236T > C多态性的频率，然后进一步评估这种关联是否特定于精神分裂症缺陷型（n = 24）和非缺陷型（n = 93）。在白种人和非裔美国人中，C等位基因在精神分裂症患者中的出现频率高于对照组，这种差异在白种人中具有统计学意义（C等位基因频率：病例中为42.0%，对照组为25.0%,P = 0.014），但在非裔美国人中没有统计学意义（病例中为52.6%，对照组为50.0%,P = 0.93）。在白种人中，C等位基因在缺陷型精神分裂症（等位基因频率为53.3%,P = 0.009）和非缺陷型精神分裂症（等位基因频率为39.2%,P = 0.050）中的频率均显著高于对照组（等位基因频率为25.0%）。我们得出结论，DRP-2 * 2236c等位基因可能标志着DRP-2或附近基因的另一种多态性，这可能影响精神分裂症的易感性。(c) 2005 Wiley-Liss, Inc。
A previous study has shown an association between the *2236T > C allele polymorphism of the dihydropyrimidinase-related protein 2 (DRP-2) gene and schizophrenia in a Japanese sample [Nakata et al. (2003); Biological Psychiatry 53:571-576]. DRP-2 is an important molecule in guiding neuronal development and its gene is located in 8p21, a chromosomal region that was previously shown to have significant linkage to schizophrenia and to several deficit symptoms of schizophrenia. We compared the frequency of the DRP-2 *2236T > C polymorphism between subjects with (n = 117) and without (n = 72) schizophrenia, and then further evaluated whether the association was specific for the deficit (n = 24) and nondeficit (n = 93) forms of schizophrenia. In both Caucasians and African-Americans, the C allele occurred more frequently in schizophrenia cases than controls, with this difference achieving statistical significance in Caucasians (C allele frequency: 42.0% in cases vs. 25.0% in controls, P = 0.014) but not African Americans (52.6% in cases vs. 50.0% in controls, P = 0.93). In Caucasians, the frequency of the C allele was significantly higher in both the deficit (allele frequency 53.3%, P = 0.009) and nondeficit (39.2%, P = 0.050) forms of schizophrenia compared to controls (allele frequency 25.0%). We conclude that the DRP-2 *2236 C allele may mark another polymorphism in DRP-2, or in a nearby gene, that may influence susceptibility to schizophrenia. (c) 2005 Wiley-Liss, Inc.