Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration
Generation of a human induced pluripotent stem cell line, BRCi004-A, derived from a patient with age-related macular degeneration
复制标题
源自年龄相关性黄斑变性患者的人类诱导多能干细胞系 BRCi004-A 的产生
DOI：
10.1016/j.scr.2020.101787
复制
发表时间：
2020
影响因子：
1.2
通讯作者：
Inoue Haruhisa
中科院分区：
文献类型：
--
作者：
Kamata Kazuma;Otsuka Yuki;Imamura Keiko;Oishi Akio;Kondo Takayuki;Suga Mika;Shibukawa Ran;Okanishi Yasue;Sagara Yukako;Tsukita Kayko;Yasukawa Tsutomu;Usui Hideaki;Muguruma Keiko;Tsujikawa Akitaka;Inoue Haruhisa
视网膜相关性黄斑变性（AMD）是一种迟发性进行性致盲疾病。我们从AMD患者中建立了人诱导多能干细胞（iPSC）。所获得的iPSC细胞系在体外具有多能性标记和三胚层分化能力。该iPSC系将有助于阐明AMD的病理机制和药物发现。
Age-related macular degeneration (AMD) is a late-onset progressive blinding disease. We established human induced pluripotent stem cells (iPSCs) from an AMD patient. The generated iPSC line showed pluripotency markers and three-germ layer differentiation abilityin vitro. This iPSC line will be useful for elucidating the pathomechanisms of and drug discovery for AMD.