Palladium-catalyzed highly regioselective 6-exo-dig cyclization and alkenylation of ortho-ethynylanilides: the synthesis of polyene-substituted benzo[d][1,3]oxazines
Palladium-catalyzed highly regioselective 6-exo-dig cyclization and alkenylation of ortho-ethynylanilides: the synthesis of polyene-substituted benzo[d][1,3]oxazines
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钯催化邻乙炔基苯胺的高度区域选择性6-exo-dig环化和烯基化：多烯取代的苯并[d][1,3]恶嗪的合成
DOI：
10.1039/c5cc06510k
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Ji, Shun-Jun
中科院分区：
文献类型：
--
作者：
Cai, Zhong-Jian;Yang, Chao;Ji, Shun-Jun
研究了钯催化邻乙炔苯胺的高区域选择性6-exo-dig环化/烯基化反应。这种串联的交叉偶联方案代表了一种简单、有效、步骤和原子经济的方法，用于以中等至优异的产率和广泛的底物范围构建几乎不为人知的多烯取代的苯并[d][1，3]恶嗪。
A Pd-catalyzed highly regioselective 6-exo-dig cyclization/alkenylation reaction of ortho-ethynylanilides has been developed. This tandem cross-coupling protocol represents a simple, efficient, step- and atom-economic approach for the construction of scarcely known polyenesubstituted benzo[d][1,3] oxazines in moderate to excellent yields with a broad substrate scope.