Molecular Mechanisms of Cardiotoxicity : A Review on the Major Side-effect of Doxorubicin
Molecular Mechanisms of Cardiotoxicity : A Review on the Major Side-effect of Doxorubicin
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2017
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通讯作者：
Maryam Mobaraki;A. Faraji;Mahkameh Zare;P. Dolati;M. Ataei;H. D. Manshadi
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作者：
Maryam Mobaraki;A. Faraji;Mahkameh Zare;P. Dolati;M. Ataei;H. D. Manshadi
2017 年 5 月至 6 月 印度药学杂志 335 阿霉素是由链霉菌（Streptomyces peucetius var.）产生的次级代谢产物。 caesius 属于蒽环类药物 (ANT) 家族。它是一种有效的抗肿瘤药物，用于治疗儿童和成人癌症，如实体瘤、白血病、淋巴瘤和乳腺癌。由于造血抑制、恶心、呕吐、外渗、脱发和心脏毒性等一些毒性，阿霉素的最佳给药受到阻碍[1]。细胞毒性化疗引起的心脏毒性发生率很高[2]。心脏毒性包括心脏的短期和长期毒性作用，从心肌结构和功能的改变到严重的心肌病和心力衰竭，可能导致心脏移植或死亡。长期服用阿霉素后会发生慢性心脏毒性。尽管发生心脏毒性的可能性与剂量有关，但由于个体差异，即使在较低剂量下也可能发生[3]。
May-June 2017 Indian Journal of Pharmaceutical Sciences 335 Doxorubicin is a secondary metabolite produced by Streptomyces peucetius var. caesius and belongs to anthracyclines (ANTs) family. It is an efficient antineoplastic agent used for the treatment of child and adult cancers such as solid tumours, leukaemia, lymphoma and breast cancer. Optimal administration of doxorubicin is hampered due to some toxicity such as hematopoietic suppression, nausea, vomiting, extravasation, alopecia, and cardiotoxicity[1]. Cytotoxic chemotherapy-induced cardiotoxicity has a high incidence[2]. Cardiotoxicity included shortand longterm toxic effects in the heart ranging from alterations in myocardial structure and function to severe cardiomyopathy and heart failure that may result in cardiac transplantation or death. Chronic cardiotoxicity occurred after prolonged administration of doxorubicin. Although the possibility of cardiotoxicity development is dose dependent, but it could occur even at lower dose due to individual variations[3].