Role of corin in the regulation of blood pressure.
Role of corin in the regulation of blood pressure.
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DOI：
10.1097/mnh.0000000000000297
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发表时间：
2017-03
影响因子：
3.2
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Li H;Zhang Y;Wu Q
Corin 是一种跨膜蛋白酶，可激活心房钠尿肽 (ANP)，这是调节盐水平衡和血压的重要激素。本综述重点关注corin功能的调节以及corin缺陷在高血压、心脏和肾脏疾病中的潜在作用。前蛋白转化酶枯草杆菌蛋白酶/kexin-6 已被确定为将酶原 corin 转化为活性蛋白酶的主要酶。在高血压、心脏肥大和先兆子痫患者中发现了损害 corin 细胞内运输、细胞表面表达和酶原激活的基因变异。在心肌病动物模型和人类衰竭心脏中检测到 corin 表达减少。据报道，心脏病和中风患者的循环可溶性corin水平较低。 Corin、ANP 和利钠肽受体-A mRNA 以及蛋白质已共定位于人肾段中，表明肾脏中存在 corin-ANP 自分泌功能。 Corin 是利钠肽系统中的关键酶。最新研究结果表明，corin 介导的 ANP 产生可能以组织特异性方式发挥作用，调节心血管和肾功能。 Corin缺陷可能导致高血压、心力衰竭、先兆子痫和肾脏疾病等重大疾病
Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia. Reduced corin expression has been detected in animal models of cardiomyopathies and in human failing hearts. Low levels of circulating soluble corin have been reported in patients with heart disease and stroke. Corin, ANP and natriuretic peptide receptor-A mRNAs, and proteins have been colocalized in human renal segments, suggesting a corin-ANP autocrine function in the kidney. Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease