Diphenhydramine and levofloxacin combination therapy against antimicrobial resistance in respiratory tract infections
Diphenhydramine and levofloxacin combination therapy against antimicrobial resistance in respiratory tract infections
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DOI：
10.2217/fmb-2019-0346
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发表时间：
2021-04-13
影响因子：
3.1
通讯作者：
Raza, Sohail
中科院分区：
文献类型：
--
作者：
Areej, Sadaf;Sattar, Adeel;Raza, Sohail
背景：数十年来，抗生素一直用于治疗由金黄色葡萄球菌和铜绿假单胞菌等革兰氏阳性和革兰氏阴性细菌引起的各种感染。苯海拉明是一种 H1 受体阻滞剂，其抗菌作用较弱，但与其他抗生素联合使用时可能会增强其抗菌活性。材料和方法：本研究调查了苯海拉明单独使用以及与左氧氟沙星联合使用时对耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌的体外抗菌活性。结果：药物对细菌的联合抗菌作用显示分数抑菌浓度指数为50%。结论：苯海拉明与左氧氟沙星联合用药具有抗菌活性，且联合用药时未发现对铜绿假单胞菌和金黄色葡萄球菌有细胞毒性。
Background: Antibiotics are in use since decades to treat various infections caused by Gram-positive and Gram-negative bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. Diphenhydramine, an H1 receptor blocker possesses a weak antibiotic action but when combined with other antibiotics may potentiate their antibacterial activity. Materials & methods: This study investigated in vitro antibacterial activity of diphenhydramine when used alone and in combination with levofloxacin against methicillin-resistant S. aureus and P. aeruginosa. Results: The combined antibacterial effect of the drugs against bacteria showed a fractional inhibitory concentration index of 50%. Conclusion: The combination of diphenhydramine and levofloxacin exerted antibacterial activity, and was not found to be cytotoxic when given in combination against P. aeruginosa and S. aureus.