PITUITARY MICROADENOMAS - A PET STUDY
PITUITARY MICROADENOMAS - A PET STUDY
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DOI：
10.1148/radiology.177.1.2399336
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发表时间：
1990-10-01
期刊：
影响因子：
19.7
通讯作者：
DICHIRO, G
中科院分区：
文献类型：
--
作者：
DESOUZA, B;BRUNETTI, A;DICHIRO, G
本文对20例经手术证实的垂体微腺瘤（17例为库欣病，3例为肢端肥大症）进行了正电子发射断层扫描（PET），并应用18-氟脱氧葡萄糖（FDG）显像。诊断结果与其他方式，即，计算机断层扫描（CT），磁共振（MR）成像，并在库欣病的情况下，同时双侧岩下窦采样（SIPS）进行了比较。PET结果显示12个阳性读数和1个可疑阅读，而CT（研究18例）显示7个阳性读数和1个可疑阅读，MR成像显示13个阳性读数和2个可疑读数。PET补充了MR成像，在这个意义上，5个阳性PET读数在MR成像中是阴性或可疑的。20名健康对照受试者的PET研究显示没有假阳性病例，而其他健康受试者的对比剂增强CT和MR成像研究分别产生了20%和15%的阳性读数，结果提示无症状或隐匿性腺瘤。
Twenty cases of surgically verified pituitary microadenoma (17 with Cushing disease and three with acromegaly) were studied with positron emission tomography (PET) with use of fluorine-18-2-fluorodeoxyglucose (FDG). The diagnostic results were compared with those of other modalities, namely, computed tomography (CT), magnetic resonance (MR) imaging, and, in the cases of Cushing disease, simultaneous bilateral inferior petrosal sinus sampling (SIPS). The PET results showed 12 positive readings and one questionable reading, compared with seven positive readings and one questionable reading for CT (18 cases studied) and 13 positive and two questionable MR imaging readings. PET complemented MR imaging, in the sense that five of the positive PET readings were negative or questionable at MR imaging. PET studies of 20 healthy control subjects showed no false-positive cases, whereas other studies of healthy subjects with contrast material-enhanced CT and MR imaging have yielded, respectively, 20% and 15% positive readings, with findings suggestive of silent or occult adenomas.