Venous thrombosis in relation to fibrinogen and factor VII genes among African-Americans
Venous thrombosis in relation to fibrinogen and factor VII genes among African-Americans
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DOI：
10.1016/s0895-4356(00)00191-8
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发表时间：
2000-10-01
影响因子：
7.2
通讯作者：
Evatt, B
中科院分区：
文献类型：
--
作者：
Austin, H;Hooper, WC;Evatt, B
我们在非裔美国人的病例对照研究中评估了静脉血栓形成与血浆纤维蛋白原水平、β 纤维蛋白原基因的 HaeIII 和 BcI 多态性以及 VII 因子基因的 MspI 多态性之间的关系。该研究包括从佐治亚州亚特兰大一家医院获得的 91 名静脉血栓病例和 185 名对照受试者。高血浆纤维蛋白原与静脉血栓形成的风险增加相关，但这一发现没有统计学意义。 HaeIII 多态性和 BclI 多态性与静脉血栓形成风险之间几乎没有关联。病例中因子VII基因M2/M2基因型的患病率高于对照组，但差异无统计学意义。在大多数研究中，β 纤维蛋白原基因的 HaeIII H2 等位基因和 BclI B2 等位基因都与血浆纤维蛋白原水平略高有关，但在这项研究中，非裔美国人中的患病率明显低于美国白人和北欧人中的患病率。该研究因其规模小而受到限制。然而，尽管存在这种限制，它仍然支持血浆纤维蛋白原水平升高与静脉血栓形成风险增加相关的观点。研究还表明，β纤维蛋白原基因的HaeIII和BclI多态性以及VII因子基因的MspI多态性并不是静脉血栓形成的强决定因素。 (C) 2000 Elsevier Science Inc. 保留所有权利。
We evaluated the relation between venous thrombosis and plasma fibrinogen levels, the HaeIII and BcI polymorphisms of the beta fibrinogen gene, and the MspI polymorphisms of the factor VII gene in a case-control study of African-Americans. The study included 91 venous thrombosis cases and 185 control subjects obtained from a hospital in Atlanta, Georgia. High plasma fibrinogen was associated with increased risk of venous thrombosis, but the finding was not statistically significant. There was little association between the HaeIII polymorphisms and the BclI polymorphisms and the risk of venous thrombosis. The prevalence of the M2/M2 genotype of the factor VII gene was higher among cases than controls, but the difference was not statistically significant. The prevalence of the HaeIII H2 allele and the BclI B2 allele of the beta fibrinogen gene, both of which have been associated with slightly higher levels of plasma fibrinogen in most studies, is considerably lower among African-Americans in this study than it is among Whites in the United States and among Northern Europeans. The study is limited by its small size. However, despite this limitation, it supports the belief that increased plasma fibrinogen levels are associated with increased venous thrombosis risk. The study also indicated that the HaeIII and the BclI polymorphisms of the beta fibrinogen gene and the MspI polymorphisms of the factor VII gene are not strong determinants of venous thrombosis. (C) 2000 Elsevier Science Inc. All rights reserved.