Paracheck-Pf®:: a new, inexpensive and reliable rapid test for P-falciparum malaria
Paracheck-Pf®:: a new, inexpensive and reliable rapid test for P-falciparum malaria
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DOI：
10.1046/j.1365-3156.2001.00694.x
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发表时间：
2001-02-01
影响因子：
3.3
通讯作者：
Nosten, F
中科院分区：
文献类型：
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作者：
Proux, S;Hkirijareon, L;Nosten, F
我们比较了Paracheck-Pf（R），一种新的和廉价的快速疟疾测试，与ICT-Pf/Pv（R）和显微镜在泰国-缅甸边境的泰国村庄的两个疟疾调查的性能。以显微镜检查结果为金标准，计算Paracheck-Pf（R）和ICT-Pf（R）试验的特异性、灵敏度、预测阳性值和阴性值。294次ICT-Pf/Pv检测结果为2次无效（无对照线）和II次可疑结果。ICT-Pf/Pv（R）和Paracheck-Pf（R）都能可靠地检测恶性疟原虫感染。然而，Paracheck-Pf（R）未能检测到三例恶性疟原虫病例，同样，ICT-Pf/Pv（R）未能检测到同样的三例病例和另外四例病例。这7例病例通过显微镜检查发现，寄生虫血症低于150个寄生虫/穆尔。成本C。Paracheck-Pf（R）检测法基于对恶性疟原虫特异性HRP-2蛋白的检测，是一种可靠、易于使用且经济实惠的诊断恶性疟原虫疟疾的工具，价值1美元。
We compared the performance of Paracheck-Pf(R), a new and cheap rapid malaria test, with ICT-Pf/Pv(R) and microscopy in two malaria surveys in Thai villages on the Thai-Burmese border. The specificity, sensitivity, predictive positive and negative values of the Paracheck-Pf(R) and ICT-Pf(R) tests were calculated taking microscopy results as the gold standard. The 294 ICT-Pf/Pv tests resulted in two invalid (no control line) and II doubtful results. Both the ICT-Pf/Pv(R) and Paracheck-Pf(R) rests reliably detected P. falciparum infections. However, Paracheck-Pf(R) failed to detect three P. falciparum cases and likewise, ICT-Pf/Pv(R) failed to detect the same three cases and an additional four cases. These seven cases were detected by microscopy and had a parasitaemia under 150 parasites/mul. At a cost of c. US $1.00, the Paracheck-Pf(R) test, based on the detection of the P. falciparum specific HRP-2 protein, is a reliable, easy to use and affordable tool for the diagnosis of P. falciparum malaria.