Foxp3+ T-Regulatory Cells in Sjogren's Syndrome Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors
Foxp3+ T-Regulatory Cells in Sjogren's Syndrome Correlation with the Grade of the Autoimmune Lesion and Certain Adverse Prognostic Factors
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DOI：
10.2353/ajpath.2008.080246
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发表时间：
2008-11-01
影响因子：
6
通讯作者：
Moutsopoulos, Haralampos M.
中科院分区：
文献类型：
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作者：
Christodoulou, Maria I.;Kapsogeorgou, Efstathia K.;Moutsopoulos, Haralampos M.
干燥综合征（SS）是一种慢性自身免疫性外分泌病，与受累器官（主要是唾液腺和泪腺）的可变淋巴细胞浸润和广泛的临床表现（包括淋巴瘤发展）相关。为了研究Foxp 3（+）T调节细胞在SS炎症反应调节中的潜在意义，我们研究了它们在小唾液腺（MSG）中的发生率及其与组织病理学和临床疾病参数的关系。在所有SS患者（n = 30）和非SS涎腺炎对照（n = 7）的MSG病变中观察到浸润Foxp 3（+）细胞的相似百分比。Foxp 3（+）细胞在干燥症患者活检阴性的对照组中未检出（n = 6）。在SS患者中，Foxp 3+细胞频率根据病变严重程度而变化，分别在中度和轻度MSG病变中获得最高和最低频率。在这些患者的外周血中，观察到Foxp 3+细胞的反向分布。此外，Foxp 3+细胞在MSG病变和外周血中的频率呈负相关（r =-0.6679，P = 0.0065）。发现MSG浸润Foxp 3（+）细胞与活检病灶评分（P = 0.05）、浸润单核细胞、树突状细胞和巨噬细胞呈正相关（P
Sjogren's syndrome (SS) is a chronic autoimmune exocrinopathy associated with variable lymphocytic infiltration of the affected organs (primarily salivary and lacrimal glands) and broad clinical manifestations, including lymphoma development. To investigate the potential implication of Foxp3(+) T-regulatory cells in the regulation of SS inflammatory responses, we studied their incidence in the minor salivary glands (MSGs) and their relationship with histopathological and clinical disease parameters. Similar percentages of infiltrating Foxp3(+) cells were observed in the MSG lesions of all SS patients (n = 30) and non-SS sialadenitis controls (n = 7). Foxp3(+) cells were not detected in sicca-complaining controls with negative biopsy (n = 6). In SS patients, Foxp3+ cell frequency varied according to lesion severity, with the highest and lowest frequencies obtained in intermediate and mild MSG lesions, respectively. In the peripheral blood of these patients, reverse distribution of Foxp3+ cells was observed. Furthermore, the frequency of Foxp3+ cells in the MSG lesions and peripheral blood was negatively associated (r = -0.6679, P = 0.0065). MSG-infiltrating Foxp3(+) cells were found to positively correlate with biopsy focus score (P = 0.05), infiltrating mononuclear cells, dendritic cells, and macrophages; (P