Gene, cell, and organ multiplication drives inner ear evolution.
Gene, cell, and organ multiplication drives inner ear evolution.
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DOI：
10.1016/j.ydbio.2017.08.034
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发表时间：
2017-11-01
影响因子：
2.7
通讯作者：
Elliott KL
中科院分区：
文献类型：
--
作者：
Fritzsch B;Elliott KL
我们回顾了耳神经感觉细胞的发展和进化，神经感觉细胞聚集成一个耳基板，新的神经感觉结构专门用于听力和新的核的进化和他们的输入专门处理这些新的听觉刺激的演变。显然新颖的听觉系统的进化在于细胞命运转录调节的重复和多样化，这允许细胞水平的变化[将单个神经感觉细胞转化为通过感觉神经元连接到其靶点的感觉细胞以及多样化的毛细胞]，器官水平[器官发育的重复，随后是多样化和新刺激的获得]和脑核水平[转录因子的增殖以调节各种神经元和神经元聚集体的命运，从而将脊髓转化为独特的后脑组织]。目前，将bHLH和其他转录因子驱动的细胞命运变化与细胞和器官变化联系起来是暂时的，因为并非所有相关因子都是已知的，并且它们的基因调控网络也只是初步了解。未来的研究可以使用这里提出的蓝图来提供更深入的分子进化理解以及对发育网络的更详细的理解。这种理解可以揭示听觉系统是如何通过现有细胞命运决定网络的转变而进化的，从而揭示神经感觉进化是如何通过影响细胞命运决定过程的分子变化而发生的。了解发育程序变化的进化级联可以确定未来恢复细胞和器官所需的基本步骤。
We review the development and evolution of the ear neurosensory cells, the aggregation of neurosensory cells into an otic placode, the evolution of novel neurosensory structures dedicated to hearing and the evolution of novel nuclei and their input dedicated to processing those novel auditory stimuli. The evolution of the apparently novel auditory system lies in duplication and diversification of cell fate transcription regulation that allows variation at the cellular level [transforming a single neurosensory cell into a sensory cell connected to its targets by a sensory neuron as well as diversifying hair cells], organ level [duplication of organ development followed by diversification and novel stimulus acquisition] and brain nuclear level [multiplication of transcription factors to regulate various neuron and neuron aggregate fate to transform the spinal cord into the unique hindbrain organization]. Tying cell fate changes driven by bHLH and other transcription factors into cell and organ changes is at the moment tentative as not all relevant factors are known and their gene regulatory network is only rudimentary understood. Future research can use the blueprint proposed here to provide both the deeper molecular evolutionary understanding as well as a more detailed appreciation of developmental networks. This understanding can reveal how an auditory system evolved through transformation of existing cell fate determining networks and thus how neurosensory evolution occurred through molecular changes affecting cell fate decision processes. Appreciating the evolutionary cascade of developmental program changes could allow identifying essential steps needed to restore cells and organs in the future.
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影响因子：
11.8
作者：
Ahmed, Mohi;Wong, Elaine Y. M.;Sun, Jianbo;Xu, Jinshu;Wang, Feng;Xu, Pin-Xian
通讯作者：
Xu, Pin-Xian
影响因子：
9.8
作者：
Albuixech-Crespo B;López-Blanch L;Burguera D;Maeso I;Sánchez-Arrones L;Moreno-Bravo JA;Somorjai I;Pascual-Anaya J;Puelles E;Bovolenta P;Garcia-Fernàndez J;Puelles L;Irimia M;Ferran JL
通讯作者：
Ferran JL
影响因子：
2.7
作者：
Cai X;Kardon AP;Snyder LM;Kuzirian MS;Minestro S;de Souza L;Rubio ME;Maricich SM;Ross SE
通讯作者：
Ross SE
DOI：
10.1523/jneurosci.0785-11.2011
发表时间：
2011-05-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Domínguez-Frutos E;López-Hernández I;Vendrell V;Neves J;Gallozzi M;Gutsche K;Quintana L;Sharpe J;Knoepfler PS;Eisenman RN;Trumpp A;Giráldez F;Schimmang T
通讯作者：
Schimmang T
DOI：
10.1002/dvdy.24306
发表时间：
2015-10
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Chen J;Streit A
通讯作者：
Streit A