TESTING FOR THE EQUALITY OF AREA UNDER THE CURVES WHEN USING DESTRUCTIVE MEASUREMENT TECHNIQUES
TESTING FOR THE EQUALITY OF AREA UNDER THE CURVES WHEN USING DESTRUCTIVE MEASUREMENT TECHNIQUES
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DOI：
10.1007/bf01062139
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发表时间：
1988-06-01
期刊：
影响因子：
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通讯作者：
BAILER, AJ
中科院分区：
文献类型：
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作者：
BAILER, AJ
在许多情况下，代谢物浓度或药物给药随时间变化的曲线下面积（AUC）具有生物学意义，对一组不同给药方案之间的AUC相等性的测试通常令人感兴趣。对于为了获得代谢物或药物浓度的估计而必须牺牲实验单元的情况，需要注意的是，可以使用特定给药方案的时间点平均浓度的线性组合来估计该方案的AUC。在这个推导中很容易构建和测试[小鼠]AUC估计值之间的对比。
The area under a curve (AUC) of metabolite concentration or drug administration over time has biological meaning in many situations, and the test of AUC equality among a set of different dosing regimens is often of interest. For the situation where the experimental unit must be sacrificied in order to obtain an estimate of the metabolite or drug concentration, it is noted that linear combinations of mean concentrations at time points for a particular dosing regimen can be used to estimate the AUC for that regimen. Contrasts among AUC estimates [in mice] are readily constructed and tested within this derivation.