The diagnosis of a personality disorder increases the likelihood for seropositivity to Toxoplasma gondii in psychiatric patients
The diagnosis of a personality disorder increases the likelihood for seropositivity to Toxoplasma gondii in psychiatric patients
复制标题
DOI：
10.14411/fp.2010.016
复制
发表时间：
2010-06-01
影响因子：
1.6
通讯作者：
Wilms, Sibylle
中科院分区：
文献类型：
--
作者：
Hinze-Selch, Dunja;Daeubener, Walter;Wilms, Sibylle
弓形虫慢性感染血清学呈阳性的个体表现出与未感染个体不同的某些人格特征。小鼠实验数据表明，TG 感染可调节行为。然而，尚未对患有人格障碍的精神病患者进行系统的研究。在我们的样本中，包括 896 名初步诊断为精神分裂症、重性抑郁症、分裂情感性或双相情感障碍的精神科住院患者和 214 名精神科未受影响的对照者（同一地理区域，在同一时间段采样），我们分析了人格障碍的额外诊断对患者的影响。在精神病学上，除了上述任何初步诊断之外，患者还可以满足人格障碍的标准。我们应用逻辑回归和跨表统计，根据是否存在人格障碍 (ICD-10) 将各组分开，并根据组间年龄进行调整。我们发现，在所有患者中，人格障碍的额外诊断与 TG 感染显着相关。此外，仅在患有其他人格障碍的患者中，中等滴度反应（1:16-1:64）与慢性病程和高C反应蛋白（CRP）水平相关，而高滴度反应（>1:64）与更急性的复发性临床病程相关。仅在老年个体中，与没有人格障碍的患者和对照组相比，人格障碍患者中的中等滴度反应（1:16-1:64）占优势。我们得出的结论是，TG 感染和宿主对其的反应对于人格障碍的诊断有影响。我们的数据支持 TG 感染可以调节人类行为和人格特征。
Individuals serologically positive for the chronic infection with the parasite Toxoplasma gondii (TG) display certain personality traits differently from uninfected individuals. Experimental data in mice demonstrate that TG infection modulates behaviour. However, psychiatric patients with a personality disorder have not yet been investigated systematically. In our sample containing 896 psychiatric inpatients with the primary diagnoses of schizophrenia, major depression, schizoaffective or bipolar disorder and 214 psychiatrically unaffected controls (same geographic region, sampled during same time period) we analysed for effects of the additional diagnosis of a personality disorder in the patients. Psychiatrically, a patient can meet the criteria of a personality disorder additionally to any of the mentioned primary diagnoses. We applied logistic regression and cross-table statistics, separated groups by the presence/absence of a personality disorder (ICD-10) and adjusted for age between groups. We found that among all patients the additional diagnosis of a personality disorder was significantly associated with TG infection. Furthermore, only in the patients with an additional personality disorder medium titre responses (1:16-1:64) were associated with chronic course and high C-reactive protein (CRP) levels whereas high titre response (>1:64) was associated with a more acute recurrent clinical course. In the older individuals only there was a preponderance of medium titre responses (1:16-1:64) among the patients with personality disorder compared to those without and controls. We conclude that TG infection and the host's response to it make a difference for the diagnosis of a personality disorder. Our data support that TG infection can modulate human behaviour and personality traits.