Synthetic bone scaffolds and fracture repair
Synthetic bone scaffolds and fracture repair
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DOI：
10.1016/j.injury.2007.02.008
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发表时间：
2007-03-01
影响因子：
2.5
通讯作者：
Bostrom, Mathias P. G.
中科院分区：
文献类型：
--
作者：
Carson, Joshua S.;Bostrom, Mathias P. G.
合成支架已被用于治疗骨缺损和骨折超过100年。它们仍然是治疗大体积骨缺损的关键工具，并且它们作为人类骨移植物的潜在替代物的作用继续扩大。商业上使用各种材料来生产骨传导支架，包括陶瓷（生物活性和生物惰性）和选择聚合物，所有这些材料都具有明显的优点和缺点。虽然目前主要用作生长的骨传导管道，但骨移植替代品在骨折治疗中的作用可能会发生变化，因为生物材料研究正在利用当前和未来的支架材料作为生物骨折治疗的输送系统。
Synthetic scaffolding has been used in the treatment of bone defects and fractures for over 100 years. They remain a critical toot in the treatment of large-volume bone defects, and their rote as potential substitues for human bone graft continues to expand. Various materials are used commercially to produce osteoconductive scaffolds including ceramics (both bioactive and bioinert) and select polymers, all of which offer distinct advantages and dissadvantages. While currently used principally as osteoconductive conduits for growth, the role of bone-graft substitues in fracture treatment is likely to change, as biomaterial research moves towards utilizing current and future scaffold materials as delivery systems for biologic fracture treatments.