Wettability and osteoblastic cell adhesion on ultrapolished commercially pure titanium surfaces: the role of the oxidation and pollution states
Wettability and osteoblastic cell adhesion on ultrapolished commercially pure titanium surfaces: the role of the oxidation and pollution states
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DOI：
10.1080/01694243.2014.893815
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发表时间：
2014-06-18
影响因子：
2.3
通讯作者：
Cabrerizo-Vilchez, Miguel A.
中科院分区：
文献类型：
--
作者：
Fernandez-Rodriguez, Miguel A.;Sanchez-Trevino, Alda Y.;Cabrerizo-Vilchez, Miguel A.
钛基生物材料表面的氧化状态强烈依赖于它们以前的历史。这一因素影响了钛的润湿性，可能是植入生物材料成功的条件。然而，金属钛表面的污染和氧化状态的单独作用仍然存在争议。为了阐明这一点，需要在粗糙度和表面化学方面标准化钛的初始表面状态，然后在相应的处理后监测其润湿性。在这项工作中，我们研究了精细抛光表面的商业纯钛（cpTi）进行清洁的表面处理。X-光电子能谱被用来表征表面化学和氧化膜厚度。在水下条件下的接触角滞后用生长/收缩捕获气泡方法测量，其允许模仿可植入装置的真实的条件。光滑cpTi表面的水润湿性通过弱热氧化（230 ℃，30分钟）稳定。分析了稳定化和非稳定化cpTi表面的成骨细胞反应。虽然氧化和污染状态也被稳定化和归一化，但在钛的润湿性和其细胞粘附性的稳定响应之间没有观察到相关性。
The oxidation state of the surfaces of titanium-based biomaterials strongly depends on their previous history. This factor affects the titanium wettability and it probably conditions the success of the implanted biomaterials. However, the separate role of the pollution and oxidation states of metallic titanium surfaces remains still controversial. To elucidate this, it is required to standardize the initial surface state of titanium in terms of roughness and surface chemistry, and then, to monitor its wettability after the corresponding treatment. In this work, we studied finely polished surfaces of commercially pure titanium (cpTi) which were subjected to cleaning surface treatments. X-Photoelectron spectroscopy was used to characterize the surface chemistry and the oxide film thickness. The contact angle hysteresis in underwater conditions was measured with the growing/shrinking captive bubble method, which allowed for mimicking the real conditions of implantable devices. The water wettability of smooth cpTi surfaces was stabilized with weak thermal oxidation (230 degrees C, 30 min). The osteoblastic cell response of the stabilized and non-stabilized cpTi surfaces was analyzed. Although the oxidation and pollution states were also stabilized and normalized, no correlation was observed between the stable response in wettability of titanium and its cell adhesion.